2020
Nonsteroidal Anti-inflammatory Drugs vs Cognitive Behavioral Therapy for Arthritis Pain
Fraenkel L, Buta E, Suter L, Dubreuil M, Levy C, Najem C, Brennan M, Corn B, Kerns R, Goulet J. Nonsteroidal Anti-inflammatory Drugs vs Cognitive Behavioral Therapy for Arthritis Pain. JAMA Internal Medicine 2020, 180: 1194-1202. PMID: 32702101, PMCID: PMC7372512, DOI: 10.1001/jamainternmed.2020.2821.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsWOMAC pain scorePain scoresAnti-inflammatory drugsGlobal ImpressionKnee osteoarthritisMeloxicam groupMcMaster Universities Osteoarthritis Index (WOMAC) pain scoreCurrent nonsteroidal anti-inflammatory drugsLong-term clinical benefitMean differencePain score differenceParticipant global impressionWOMAC disability scoresKnee osteoarthritis painLower extremity disabilityPrimary outcome measureSignificant differencesCognitive behavioral therapy programCognitive behavioral therapyBehavioral therapy programBaseline painOsteoarthritis painTreat basisDisability scoresBrief educational video plus telecare to enhance recovery for older emergency department patients with acute musculoskeletal pain: study protocol for the BETTER randomized controlled trial
Platts-Mills TF, McLean SA, Weinberger M, Stearns SC, Bush M, Teresi BB, Hurka-Richardson K, Kroenke K, Kerns RD, Weaver MA, Keefe FJ. Brief educational video plus telecare to enhance recovery for older emergency department patients with acute musculoskeletal pain: study protocol for the BETTER randomized controlled trial. Trials 2020, 21: 615. PMID: 32631400, PMCID: PMC7336469, DOI: 10.1186/s13063-020-04552-3.Peer-Reviewed Original ResearchConceptsChronic musculoskeletal painMusculoskeletal painEmergency departmentUsual careOpioid useChronic painOlder adultsAnalgesic-related side effectsLong-term opioid useOlder emergency department (ED) patientsAcute musculoskeletal painEmergency department patientsCause of disabilityPublic health priorityBrief educational videoDiscussionThis trialPain severitySecondary outcomesSixty patientsDepartment patientsPrimary outcomeHealthcare utilizationStudy enrollmentPhysical functionStudy protocol
2019
Graded chronic pain scale revised: mild, bothersome, and high-impact chronic pain.
Von Korff M, DeBar LL, Krebs EE, Kerns RD, Deyo RA, Keefe FJ. Graded chronic pain scale revised: mild, bothersome, and high-impact chronic pain. Pain 2019, 161: 651-661. PMID: 31764390, PMCID: PMC7097879, DOI: 10.1097/j.pain.0000000000001758.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChronic PainFemaleHumansMaleMiddle AgedPain MeasurementReproducibility of ResultsYoung AdultConceptsHigh-impact chronic painMild chronic painChronic Pain ScaleGraded Chronic Pain ScaleChronic painPain Scale-RevisedPain scaleLong-term opioid therapySubstantial activity limitationsHealth status indicatorsOpioid therapyAdult enrolleesActivity limitationsPainPain metricsHealth plansNonsignificant differenceStatus indicatorsPersonsValid methodTherapyPrevalenceBothersomeEnrolleesFurther Examination of the Pain Stages of Change Questionnaires Among Chronic Low Back Pain Patients
Mun CJ, Otis JD, Concato J, Reid MC, Burg MM, Czlapinski R, Kerns RD. Further Examination of the Pain Stages of Change Questionnaires Among Chronic Low Back Pain Patients. The Clinical Journal Of Pain 2019, 35: 744-752. PMID: 31149934, DOI: 10.1097/ajp.0000000000000733.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsSelf-management approachBack pain patientsCognitive behavioral therapyChronic painDepressive symptom severityPain severityPain patientsPain StagesRegular cognitive behavioural therapySymptom severityVA primary care clinicsChange scoresPrimary care clinicsChange QuestionnaireLong-term functionMaintenance scoresCare clinicsPresent studyPatient readinessPatients' attitudesWeeks posttreatmentSustained benefitTherapeutic mechanismCore Outcome Measures for Chronic Musculoskeletal Pain Research: Recommendations from a Veterans Health Administration Work Group
Kroenke K, Krebs EE, Turk D, Von Korff M, Bair MJ, Allen KD, Sandbrink F, Cheville AL, DeBar L, Lorenz KA, Kerns RD. Core Outcome Measures for Chronic Musculoskeletal Pain Research: Recommendations from a Veterans Health Administration Work Group. Pain Medicine 2019, 20: 1500-1508. PMID: 30615172, DOI: 10.1093/pm/pny279.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyBiomedical ResearchChronic PainDelphi TechniqueDepressionHumansMusculoskeletal PainOutcome Assessment, Health CarePain ManagementPain MeasurementPatient Health QuestionnairePatient Reported Outcome MeasuresPhysical Functional PerformancePsychometricsSleepUnited StatesUnited States Department of Veterans AffairsConceptsCore Outcome MeasuresOutcome measuresPain intensityPatient-reported global impressionBrief Pain Inventory Interference ScaleChronic musculoskeletal pain disordersMusculoskeletal pain disordersChronic musculoskeletal painPatient Health QuestionnaireNumerical rating scaleVeterans Health AdministrationCommon outcome measuresGeneralized anxiety disorderMusculoskeletal painPain disordersChronic painGlobal ImpressionPhysical functionHealth QuestionnairePhysical functioningSleep ScaleDepression ScaleOutcomes Information SystemPain researchHealth Administration
2018
Impact of Cigarette Smoking Status on Pain Intensity Among Veterans With and Without Hepatitis C
Lynch SM, Wilson SM, DeRycke EC, Driscoll MA, Becker WC, Goulet JL, Kerns RD, Mattocks KM, Brandt CA, Bathulapalli H, Skanderson M, Haskell SG, Bastian LA. Impact of Cigarette Smoking Status on Pain Intensity Among Veterans With and Without Hepatitis C. Pain Medicine 2018, 19: s5-s11. PMID: 30203017, DOI: 10.1093/pm/pny146.Peer-Reviewed Original ResearchConceptsHepatitis C virusSevere pain intensityPain intensityElectronic medical recordsCurrent smokersSmoking statusVeterans Health Administration primary care clinicsOperations Enduring Freedom/Iraqi Freedom/New DawnIndependent risk factorInteraction of smokingNumeric rating scalePrimary care clinicsHigher pain intensityCigarette smoking statusICD-9 codesOEF/OIF/OND veteransCross-sectional analysisCohort studyCurrent smokingHepatitis C.Severe painPain managementTobacco smokingCare clinicsChronic pain
2017
Classifying clinical notes with pain assessment using machine learning
Fodeh SJ, Finch D, Bouayad L, Luther SL, Ling H, Kerns RD, Brandt C. Classifying clinical notes with pain assessment using machine learning. Medical & Biological Engineering & Computing 2017, 56: 1285-1292. PMID: 29280092, PMCID: PMC6014866, DOI: 10.1007/s11517-017-1772-1.Peer-Reviewed Original ResearchConceptsPain care qualityPain assessmentClinical notesChronic painMusculoskeletal diagnosesSignificant public health problemCharacteristics of patientsIntensity of painType of painPublic health problemPain sitesPain complaintsPatient reportsPainPatientsHealth problemsCare qualityFiscal year 2011Health recordsMillions of peopleComplete dataClinical applicationDiagnosisDemographic variablesWide spectrumTaking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephone-based coaching intervention for chronic musculoskeletal pain among African Americans
Bhimani RH, Cross LJ, Taylor BC, Meis LA, Fu SS, Allen KD, Krein SL, Do T, Kerns RD, Burgess DJ. Taking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephone-based coaching intervention for chronic musculoskeletal pain among African Americans. BMC Musculoskeletal Disorders 2017, 18: 15. PMID: 28086853, PMCID: PMC5237146, DOI: 10.1186/s12891-016-1363-6.Peer-Reviewed Original ResearchConceptsChronic musculoskeletal painMusculoskeletal painTreatment outcomesHealth care service utilizationMorris Disability QuestionnairePain outcome measuresPain treatment outcomesTelephone counseling sessionsAfrican American patientsAfrican AmericansPrimary aimUsual careDisability QuestionnaireOpioid analgesicsPain outcomesPain treatmentPrimary outcomeChronic painPain assessmentTreat methodologyAmerican patientsClinical trialsPhysical functioningService utilizationOutcome measuresClassifying Clinical Notes with Pain Assessment.
Fodeh SJ, Finch D, Bouayad L, Luther S, Kerns RD, Brandt C. Classifying Clinical Notes with Pain Assessment. 2017, 245: 1261. PMID: 29295346.Peer-Reviewed Original ResearchMeSH KeywordsChronic PainElectronic Health RecordsHumansMachine LearningPain MeasurementQuality of Health CareReproducibility of Results
2016
Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder.
Barry DT, Cutter CJ, Beitel M, Kerns RD, Liong C, Schottenfeld RS. Psychiatric Disorders Among Patients Seeking Treatment for Co-Occurring Chronic Pain and Opioid Use Disorder. The Journal Of Clinical Psychiatry 2016, 77: 1413-1419. PMID: 27574837, PMCID: PMC6296217, DOI: 10.4088/jcp.15m09963.Peer-Reviewed Original ResearchConceptsOpioid use disorderCo-occurring chronic painChronic painAxis I DisordersUse disordersPsychiatric disordersI disordersMood disordersCo-occurring opioid use disorderBuprenorphine/naloxone treatmentNonopioid substance use disordersDSM-IV-TR Axis I DisordersCo-occurring psychiatric disordersAnxiety disordersMajority of patientsPersonality disorderMethadone maintenance treatmentTreatment of patientsComorbid psychiatric disordersLifetime mood disordersMajor depressive disorderStructured Clinical InterviewLifetime anxiety disorderSubstance use disordersTreatment Research ProgramPain intensity rating training
Smith SM, Amtmann D, Askew RL, Gewandter JS, Hunsinger M, Jensen MP, McDermott MP, Patel KV, Williams M, Bacci ED, Burke LB, Chambers CT, Cooper SA, Cowan P, Desjardins P, Etropolski M, Farrar JT, Gilron I, Huang IZ, Katz M, Kerns RD, Kopecky EA, Rappaport BA, Resnick M, Strand V, Vanhove GF, Veasley C, Versavel M, Wasan AD, Turk DC, Dworkin RH. Pain intensity rating training. Pain 2016, 157: 1056-1064. PMID: 27058680, DOI: 10.1097/j.pain.0000000000000502.Peer-Reviewed Original ResearchConceptsPain intensity ratingsAverage pain intensity ratingsPain assessmentPainful diabetic peripheral neuropathyAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipDiabetic peripheral neuropathyIntensity ratingsLow back painPatient-reported outcomesClinical trial participantsPeripheral neuropathyPain fluctuationsTreatment trialsTrial participantsSignificant differencesStandardized guidanceDiscriminant validityParticipantsGroupMost measuresNeuropathyAnalgesicsPainAssessmentCooperative pain education and self-management (COPES): study design and protocol of a randomized non-inferiority trial of an interactive voice response-based self-management intervention for chronic low back pain
Heapy AA, Higgins DM, LaChappelle KM, Kirlin J, Goulet JL, Czlapinski RA, Buta E, Piette JD, Krein SL, Richardson CR, Kerns RD. Cooperative pain education and self-management (COPES): study design and protocol of a randomized non-inferiority trial of an interactive voice response-based self-management intervention for chronic low back pain. BMC Musculoskeletal Disorders 2016, 17: 85. PMID: 26879051, PMCID: PMC4754867, DOI: 10.1186/s12891-016-0924-z.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painNon-inferiority trialRandomized non-inferiority trialCognitive behavioral therapyPerson cognitive-behavioural therapyBack painClinical outcomesChronic pain conditionsNumeric rating scalePain-related interferencePatient-reported informationSelf-management interventionsEvidence-based treatmentsQuality of lifeUS military veteransStatewide health systemBackgroundThe InstituteIVR monitoringSecondary outcomesMore patientsPain conditionsPain intensityPrimary outcomeChronic painResearch design considerations for single-dose analgesic clinical trials in acute pain
Cooper SA, Desjardins PJ, Turk DC, Dworkin RH, Katz NP, Kehlet H, Ballantyne JC, Burke LB, Carragee E, Cowan P, Croll S, Dionne RA, Farrar JT, Gilron I, Gordon DB, Iyengar S, Jay GW, Kalso EA, Kerns RD, McDermott MP, Raja SN, Rappaport BA, Rauschkolb C, Royal MA, Segerdahl M, Stauffer JW, Todd KH, Vanhove GF, Wallace MS, West C, White RE, Wu C. Research design considerations for single-dose analgesic clinical trials in acute pain. Pain 2016, 157: 288-301. PMID: 26683233, DOI: 10.1097/j.pain.0000000000000375.Peer-Reviewed Original ResearchConceptsClinical trialsEarly phase clinical trialsAcute pain studiesAcute pain trialsPain clinical trialsAnalgesic clinical trialsPhase clinical trialsShort-duration trialsPostoperative painAcute painPain trialsPain assessmentStudy design factorsPain studiesDental impactionStudy designTrialsPainAssessment measuresResearch design considerationsPlaceboSurgeryBunionectomyDifferent settingsInitial development of patient-reported instrument assessing harm, efficacy, and misuse of long-term opioid therapy
Becker WC, Fiellin DA, Black AC, Kostovich CT, Kerns RD, Fraenkel L. Initial development of patient-reported instrument assessing harm, efficacy, and misuse of long-term opioid therapy. The Journal Of Rehabilitation Research And Development 2016, 53: 127-136. PMID: 27006339, PMCID: PMC4806533, DOI: 10.1682/jrrd.2014.11.0285.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyPatient-reported instrumentOpioid therapyFurther item reductionIneffective medicationsClinical outcomesPrimary careFrequent reassessmentPatient comprehensionItem reductionGold standardEfficacyTherapyInterdisciplinary teamLevel checksCognitive interviewsMisuseHarmMedicationsPatientsAdvances in pain management for Veterans: Current status of research and future directions
Kerns RD, Heapy A, Kerns RD, Heapy AA. Advances in pain management for Veterans: Current status of research and future directions. The Journal Of Rehabilitation Research And Development 2016, 53: vii-x. PMID: 27004523, DOI: 10.1682/jrrd.2015.10.0196.Commentaries, Editorials and LettersStepped care model of pain management and quality of pain care in long-term opioid therapy
Moore BA, Anderson D, Dorflinger L, Zlateva I, Lee A, Gilliam W, Tian T, Khatri K, Ruser CB, Kerns RD. Stepped care model of pain management and quality of pain care in long-term opioid therapy. The Journal Of Rehabilitation Research And Development 2016, 53: 137-146. PMID: 27006068, DOI: 10.1682/jrrd.2014.10.0254.Peer-Reviewed Original Research
2015
Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review
Dworkin JD, McKeown A, Farrar JT, Gilron I, Hunsinger M, Kerns RD, McDermott MP, Rappaport BA, Turk DC, Dworkin RH, Gewandter JS. Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review. Journal Of Clinical Epidemiology 2015, 72: 56-65. PMID: 26597977, DOI: 10.1016/j.jclinepi.2015.10.019.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPain treatmentPrimary analysisSystematic reviewNonpharmacologic pain treatmentsRecent randomized trialsJournal of PainQuality of reportingHalf of studiesClinical trial publicationsPercent of studiesNoninterventional trialStatistical methodsPrimary outcomeRandomized trialsClinical trialsTrial publicationsPainTrial resultsTrialsStatistical methodologyTreatmentReviewDeficiencyReportingNational Dissemination of Cognitive-Behavioral Therapy for Chronic Pain in Veterans
Stewart MO, Karlin BE, Murphy JL, Raffa SD, Miller SA, McKellar J, Kerns RD. National Dissemination of Cognitive-Behavioral Therapy for Chronic Pain in Veterans. The Clinical Journal Of Pain 2015, 31: 722-729. PMID: 25171637, DOI: 10.1097/ajp.0000000000000151.Peer-Reviewed Original ResearchConceptsPain-related outcomesCBT-CPQuality of lifeCognitive behavioral therapyHealth care systemVeteran patientsChronic painVeterans Affairs Health Care SystemPatient-reported pain intensityVA health care systemCare systemTherapeutic alliancePain-related cognitionsPain intensityTreat analysisPain interferencePain catastrophizingPatient outcomesSpecialty settingsOverall distressTraining programPatientsWeekly consultationEffect of trainingNational dissemination
2014
Using Multiple Daily Pain Ratings to Improve Reliability and Assay Sensitivity: How Many Is Enough?
Heapy A, Dziura J, Buta E, Goulet J, Kulas JF, Kerns RD. Using Multiple Daily Pain Ratings to Improve Reliability and Assay Sensitivity: How Many Is Enough? Journal Of Pain 2014, 15: 1360-1365. PMID: 25283469, DOI: 10.1016/j.jpain.2014.09.012.Peer-Reviewed Original ResearchConceptsPain intensity ratingsPain treatment trialsPain ratingsTreatment trialsIntensity ratingsDaily pain ratingsMedical Center patientsIMMPACT recommendationsBaseline measurement periodCenter patientsPain assessmentBland-Altman analysisClinical trialsSecondary data analysisDaily callsDaily ratingsTrialsMeaningful differencesAssay sensitivityMeasure reliabilityAdequate reliabilitySpecific recommendationsPatientsSmall subsetBaselineEffect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study
Farrar JT, Troxel AB, Haynes K, Gilron I, Kerns RD, Katz NP, Rappaport BA, Rowbotham MC, Tierney AM, Turk DC, Dworkin RH. Effect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study. Pain 2014, 155: 1622-1631. PMID: 24831421, DOI: 10.1016/j.pain.2014.05.009.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathyLikelihood of responseClinical trialsPostherpetic neuralgiaPainful diabetic peripheral neuropathyAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipBaseline pain levelsPlacebo-treated groupRandomized clinical trialsAnalgesic clinical trialsPatient-level dataClinical trial dataExploratory logistic regressionAvailable baseline factorsNeuropathic painPain diaryPain levelsBaseline factorsPain therapyPeripheral neuropathyPatient sexPatients' baselinePain ratingsStudy protocol