2009
Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer
Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP. Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer. Science 2009, 323: 1218-1222. PMID: 19164706, PMCID: PMC2756524, DOI: 10.1126/science.1157669.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisCarcinoma, Renal CellCell LineCompound Eye, ArthropodDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianFushi Tarazu Transcription FactorsGene Expression ProfilingGene Regulatory NetworksHomeodomain ProteinsHumansJanus KinasesKidneyKidney NeoplasmsMolecular Sequence DataNervous SystemNuclear ProteinsPhosphoprotein PhosphatasesPhosphorylationRepressor ProteinsSignal TransductionTranscription FactorsTranscription, GeneticConceptsTranscription factorsClear cell renal cell carcinomaCell renal cell carcinomaKey transcription factorDrosophila segmentation networkConserved roleEmbryonic segmentationDrosophila melanogasterUbiquitin E3JNK signalingDependent apoptosisSPOPRenal cell carcinomaSPOP expressionKidney cancerTumor necrosis factorNew roleDrosophilaMelanogasterPuckeredGenesSignalingOverexpressedIdentificationApoptosis
2002
RET Activation and Clinicopathologic Features in Poorly Differentiated Thyroid Tumors
Santoro M, Papotti M, Chiappetta G, Garcia-Rostan G, Volante M, Johnson C, Camp RL, Pentimalli F, Monaco C, Herrero A, Carcangiu ML, Fusco A, Tallini G. RET Activation and Clinicopathologic Features in Poorly Differentiated Thyroid Tumors. The Journal Of Clinical Endocrinology & Metabolism 2002, 87: 370-379. PMID: 11788678, DOI: 10.1210/jcem.87.1.8174.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, PapillaryCell DifferentiationDrosophila ProteinsFemaleGene RearrangementHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedOncogene Proteins, FusionPrognosisProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-retReceptor Protein-Tyrosine KinasesReverse Transcriptase Polymerase Chain ReactionSurvival AnalysisThyroid NeoplasmsConceptsRET/PTC rearrangementsRET/PTCClinicopathologic parametersRET activationInsular growth patternRelevant clinicopathologic parametersClinical characteristicsClinicopathologic featuresDistant metastasisSignificant morbidityDifferentiated tumorsHistologic evidenceMale sexAnaplastic carcinomaPatient outcomesPoor survivalEpithelial neoplasmsPapillary carcinomaLow prevalenceOncocytic featuresThyroid tumorsSurvival analysisThyroid glandMorphologic featuresSame tumor