1999
Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent.
Sutton R, Reitsma M, Uchida N, Brown P. Transduction of human progenitor hematopoietic stem cells by human immunodeficiency virus type 1-based vectors is cell cycle dependent. Journal Of Virology 1999, 73: 3649-60. PMID: 10196257, PMCID: PMC104140, DOI: 10.1128/jvi.73.5.3649-3660.1999.Peer-Reviewed Original ResearchConceptsProgenitor hematopoietic stem cellsHematopoietic stem cellsCell cycleG0 cellsStem cellsTransduction ratesG2/M phaseReplication intermediatesCellular factorsHuman immunodeficiency virus type 1 vectorsTransduction efficiencyTransductionAddition of cytokinesM phaseHuman immunodeficiency virus type 1Immunodeficiency virus type 1Presence of cytokinesLentivirus vectorFurther characterizationReverse transcriptionDistinct subpopulationsG2/M fractionVirus type 1CellsTime of initiation
1998
Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells.
Sutton R, Wu H, Rigg R, Böhnlein E, Brown P. Human immunodeficiency virus type 1 vectors efficiently transduce human hematopoietic stem cells. Journal Of Virology 1998, 72: 5781-8. PMID: 9621037, PMCID: PMC110379, DOI: 10.1128/jvi.72.7.5781-5788.1998.Peer-Reviewed Original ResearchConceptsHuman hematopoietic stem cellsHematopoietic stem cellsStem cellsMarker gene expressionLentivirus vector systemGene transfer agentsMarker gene productLong-term persistenceGene productsGene expressionHuman immunodeficiency virus type 1 vectorsIntegrated provirusStable expressionVector systemTransduction ratesCellsExpressionHuman immunodeficiency virus type 1Immunodeficiency virus type 1Virus type 1MitosisTransductionDeletionOncoretrovirusesVpr