2018
Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice
Gaspar R, Muñoz V, Kuga G, Nakandakari S, Minuzzi L, Botezelli J, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice. Journal Of Cellular Biochemistry 2018, 120: 697-704. PMID: 30206970, DOI: 10.1002/jcb.27426.Peer-Reviewed Original ResearchConceptsAcute physical exerciseBrown adipose tissueObese micePhysical exerciseEnergy expenditureERK1/2 phosphorylationTreatment of obesityExtracellular signal-regulated kinase1/2 (ERK1/2) phosphorylationProtein 1 (UCP1) contentExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Sympathetic signalsSpontaneous activityAdipose tissueP-ERK1/2Main interventionThermoregulatory effectsMiceKey mediatorThermogenesisOxygen uptakeMolecular changesKinase 1/2ObeseObesity
2017
High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage
Gaspar R, Botezelli J, Kuga G, Muñoz V, Coope A, Pereira R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. High Dosage of Vitamin D Regulates the Energy Metabolism and Increases Insulin Sensitivity, but are Associated with High Levels of Kidney Damage. Drug Development Research 2017, 78: 203-209. PMID: 28718949, DOI: 10.1002/ddr.21394.Peer-Reviewed Original ResearchConceptsMetabolic disordersHigh dosesRole of VitDVitamin D deficiencyImportant therapeutic targetD deficiencyRenal damageObese miceC57BL/6J miceInsulin sensitivityMetabolic benefitsTherapeutic strategiesTherapeutic targetVitDMiceDosesBody massDisordersLarge proportionCalcitriolObeseKidneyDiseaseDoseAdministration