2022
The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer
Lo U, Chen Y, Cen J, Deng S, Luo J, Zhau H, Ho L, Lai C, Mu P, Chung L, Hsieh J. The driver role of JAK‐STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy‐ and castration‐resistant prostate cancer. Clinical And Translational Medicine 2022, 12: e978. PMID: 35908276, PMCID: PMC9339240, DOI: 10.1002/ctm2.978.Peer-Reviewed Original ResearchConceptsCastration-resistant prostate cancerProstate cancerCancer stem cellsActivation of JAKJAK-STAT signalingGene set enrichment analysisJAK-STAT1 pathwaySTAT1 inhibitorAcquisition of stemness propertiesProstate cancer cell linesProstate cancer stemnessAssociated with cancer stem cellsIn vivo anti-tumor activityMetastatic prostate cancerTumor-initiating capabilityJAK-STATProstasphere assayDownstream effectorsIngenuity PathwayGenetic manipulationCSC genesBioinformatics analysisEnrichment analysisJAK-STAT1Signaling pathway
2010
Widespread regulatory activity of vertebrate microRNA* species
Yang J, Phillips M, Betel D, Mu P, Ventura A, Siepel A, Chen K, Lai E. Widespread regulatory activity of vertebrate microRNA* species. RNA 2010, 17: 312-326. PMID: 21177881, PMCID: PMC3022280, DOI: 10.1261/rna.2537911.Peer-Reviewed Original ResearchConceptsAnalysis of microarray dataVertebrate regulatory networksStudy of miRNA functionMiRNA:miRNARelevant to oncogenesisFraction of miRNAsTranscriptome-wide evidenceRegulatory networksMicroarray dataVertebrate evolutionSilencing complexMiRNA functionMiR-19RNA duplexesExpression constructsBioinformatics analysisMature miRNAsStrand speciesVertebratesSpeciesObligate intermediateSensor assayMutagenesis testsRepressionSeed sites