2001
Glutamate regulates actin-based motility in axonal filopodia
Chang S, De Camilli P. Glutamate regulates actin-based motility in axonal filopodia. Nature Neuroscience 2001, 4: 787-793. PMID: 11477424, DOI: 10.1038/90489.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBridged Bicyclo Compounds, HeterocyclicCalciumCalcium ChannelsCell DifferentiationCell MovementCells, CulturedCentral Nervous SystemGlutamic AcidGreen Fluorescent ProteinsGrowth ConesHippocampusImmunohistochemistryLuminescent ProteinsNeuronal PlasticityPseudopodiaRatsReceptors, AMPAReceptors, N-Methyl-D-AspartateTau ProteinsThiazolesThiazolidinesConceptsAdult nervous systemGlutamate receptorsNervous systemAxonal filopodiaAMPA/kainate glutamate receptorsKainate glutamate receptorsEffects of glutamateIonotropic glutamate receptorsCNQX treatmentSynaptic vesicle clustersAxonal arborsAxonal branchesDendritic spinesExtracellular Ca2Neurotransmitter glutamateSynaptic formationSynaptic plasticityInhibitory effectGlutamateReceptorsVesicle clustersNMDASynaptogenesisSpine
1989
Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate
Burger P, Mehl E, Cameron P, Maycox P, Baumert M, Lottspeich F, De Camilli P, Jahn R. Synaptic vesicles immunoisolated from rat cerebral cortex contain high levels of glutamate. Neuron 1989, 3: 715-720. PMID: 2577130, DOI: 10.1016/0896-6273(89)90240-7.Peer-Reviewed Original ResearchConceptsSynaptic vesiclesRat cerebral cortexRat brain synaptic vesiclesProton electrochemical gradientBrain synaptic vesiclesCerebral cortexCytosolic poolMajor excitatory neurotransmitterVesicle membraneElectrochemical gradientAmino acidsVesiclesVesicle hypothesisMammalian CNSExcitatory neurotransmitterGlutamate lossEnrichment of glutamateN-ethylmaleimideStarting fractionGlutamate contentGlutamateHigh levelsL-glutamateCortexExchange experiments