2014
Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users
Canavan SV, Forselius EL, Bessette AJ, Morgan PT. Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users. Addictive Behaviors 2014, 39: 1057-1061. PMID: 24642345, PMCID: PMC4026273, DOI: 10.1016/j.addbeh.2014.02.015.Peer-Reviewed Original ResearchConceptsBalloon Analogue Risk TaskBART scoresHealthy participantsCocaine-dependent individualsCocaine dependenceChronic cocaine usersEffects of modafinilCognitive effectsRisk TaskBehavioral measuresChronic cocaine useDependent individualsWake-promoting agentNormalization of riskRisk takingSubstance useCognitive impairmentPreliminary evidenceCocaine usersHigher scoresModafinilParticipantsCocaine useSleep disordersModafinil treatment
2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
2012
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
Fox HC, Seo D, Tuit K, Hansen J, Kimmerling A, Morgan PT, Sinha R. Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings. Journal Of Psychopharmacology 2012, 26: 958-972. PMID: 22234929, PMCID: PMC3694403, DOI: 10.1177/0269881111430746.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-2 Receptor AgonistsAdultCocaine-Related DisordersCombined Modality TherapyConnecticutDiagnostic and Statistical Manual of Mental DisordersDose-Response Relationship, DrugDouble-Blind MethodFemaleGuanfacineHumansImagery, PsychotherapyMagnetic Resonance ImagingMaleMiddle AgedNeuronsPilot ProjectsPrefrontal CortexStress, PsychologicalSubstance Withdrawal SyndromeConceptsCocaine-dependent individualsPrefrontal activityDrug cravingFunctional magnetic resonance imaging sessionDrug cue-induced cravingTreatment-seeking cocaine dependent individualsCue-induced drug cravingDependent individualsMagnetic resonance imaging sessionLateral prefrontal activityCue-induced cravingDrug cue exposureGuanfacine's effectsDrug cuesSubjective cravingImagery conditionPrefrontal activationCue exposurePhysiological arousalCognitive challengesBrain responsesAgonist guanfacineNicotine cravingGuanfacine groupCraving