2020
Does Specimen Type Have an Impact on HER2 Status in Endometrial Serous Carcinoma? Discordant HER2 Status of Paired Endometrial Biopsy and Hysterectomy Specimens in the Presence of Frequent Intratumoral Heterogeneity
Rottmann D, Assem H, Matsumoto N, Wong S, Hui P, Buza N. Does Specimen Type Have an Impact on HER2 Status in Endometrial Serous Carcinoma? Discordant HER2 Status of Paired Endometrial Biopsy and Hysterectomy Specimens in the Presence of Frequent Intratumoral Heterogeneity. International Journal Of Gynecological Pathology 2020, 40: 263-271. PMID: 32897955, DOI: 10.1097/pgp.0000000000000690.Peer-Reviewed Original ResearchConceptsEndometrial serous carcinomaDiscordant HER2 statusHER2 immunohistochemical scoresHER2 protein expressionSerous carcinomaHER2 statusEndometrial biopsies/curettingsImmunohistochemical scoreProtein expressionHER2 testingIntratumoral heterogeneityEndometrial biopsy/curettageProlonged progression-free survivalHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2HER2 testing algorithmProgression-free survivalGrowth factor receptor 2HER2-negative tumorsFinal study cohortHER2-positive tumorsRecent clinical trialsSpecimen typesFactor receptor 2Optimal specimen types
2014
Hormonal Therapy for Aggressive Angiomyxoma
Schwartz PE, Hui P, McCarthy S. Hormonal Therapy for Aggressive Angiomyxoma. Journal Of Lower Genital Tract Disease 2014, 18: e55-e61. PMID: 24402356, DOI: 10.1097/lgt.0b013e3182a22019.Peer-Reviewed Original ResearchConceptsHormonal therapyMenopausal statusAggressive angiomyxomaPatient's menopausal statusRecurrent aggressive angiomyxomaEstrogen receptorRecurrent diseaseLeuprolide acetateProgestin receptor contentInitial surgical resectionExtent of diseaseTreatment of patientsMonthly leuprolideAdjuvant therapyNeoadjuvant therapyPelvic recurrencePostmenopausal womenPremenopausal womenSurgical resectionDefinitive treatmentHormonal agentsReceptor contentSensitive tumorsAromatase inhibitorsProgestin receptors