2024
Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations.
Niu N, Buza N, Hui P. Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations. International Journal Of Gynecological Pathology 2024 PMID: 38959396, DOI: 10.1097/pgp.0000000000001044.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorSerum human chorionic gonadotropinHuman chorionic gonadotropinTrophoblastic tumorImmune checkpoint inhibitor therapyActinomycin D therapyMethotrexate-based chemotherapyVariable clinicopathological presentationsCheckpoint inhibitor therapyGestational trophoblastic tumorsSerum hCG levelsExtrauterine metastasesMultiagent chemotherapyVaginal bleedingHCG levelsHydatidiform moleInhibitor therapyCervical massUterine massGestational originEndometrial biopsyClinicopathological presentationPatient ageDisease-free
2021
Gestational Trophoblastic Neoplasms
Hui P. Gestational Trophoblastic Neoplasms. 2021, 791-820. DOI: 10.1007/978-3-030-84725-8_29.Peer-Reviewed Original ResearchEpithelioid trophoblastic tumorPlacental site nodulePlacental site trophoblastic tumorExaggerated placental site reactionAtypical placental site noduleGestational trophoblastic neoplasiaTrophoblastic tumorGestational choriocarcinomaPersistent gestational trophoblastic neoplasiaEarly chemotherapeutic interventionGestational trophoblastic tumorsGestational trophoblastic neoplasmsBenign reactive conditionsDistinct neoplastic entitySite reactionsTrophoblastic neoplasiaIntermediate trophoblastTrophoblastic neoplasmsPathological diagnosisPrecursor lesionsAncillary studiesNeoplastic entitiesPatient managementHigh indexHistological characteristics
2018
Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology
Hui P. Gestational Trophoblastic Tumors: A Timely Review of Diagnostic Pathology. Archives Of Pathology & Laboratory Medicine 2018, 143: 65-74. PMID: 30407075, DOI: 10.5858/arpa.2018-0234-ra.Peer-Reviewed Original ResearchConceptsGestational trophoblastic tumorsTrophoblastic tumorPersistent gestational trophoblastic neoplasiaPlacental site trophoblastic tumorAtypical placental site noduleEarly chemotherapeutic interventionPlacental site noduleEpithelioid trophoblastic tumorGestational trophoblastic neoplasiaClinical featuresGestational choriocarcinomaTrophoblastic neoplasiaHistologic characteristicsPathologic diagnosisClinical managementPrecursor lesionsHigh indexClinical practiceAccurate diagnosisTumorsChemotherapeutic interventionSurveillance programDistinct entityMolecular biomarkersDiagnostic recognition
2016
Putative Precursor Lesions of Gestational Trophoblastic Neoplasia
Buza N, Hui P. Putative Precursor Lesions of Gestational Trophoblastic Neoplasia. 2016, 85-102. DOI: 10.1007/978-3-319-22509-8_5.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorEpithelioid trophoblastic tumorPlacental site nodulePrecursor lesionsTrophoblastic tumorRare caseAtypical placental site noduleRisk of progressionExaggerated placental siteGestational trophoblastic neoplasiaGestational trophoblastic neoplasmsSignificant cytological atypiaHistological diagnostic criteriaMajority of tumorsPossible precursor lesionsPutative precursor lesionsIntraplacental choriocarcinomaEctopic pregnancyTerm pregnancyTrophoblastic neoplasiaGestational choriocarcinomaNon-molar abortionsPlacental siteTrophoblastic neoplasmsCytological atypia
2011
Tumor-Like Trophoblastic Conditions
Hui P. Tumor-Like Trophoblastic Conditions. Current Clinical Pathology 2011, 147-159. DOI: 10.1007/978-1-61779-394-3_10.Peer-Reviewed Original ResearchPlacental site nodulePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastExaggerated placental site reactionNon-trophoblastic neoplasmsSquamous cell carcinomaPrior pregnancyCell carcinomaSite reactionsIncidental findingProliferative lesionsNeoplastic counterpartsImplantation sitesCytological featuresLesionsTumorsTrophoblastConcurrent gestationReactive conditionsClinicopathologicallyPregnancyReactive processCarcinomaGenetic Basis of Gestational Trophoblastic Disease
Hui P. Genetic Basis of Gestational Trophoblastic Disease. Current Clinical Pathology 2011, 41-55. DOI: 10.1007/978-1-61779-394-3_3.Peer-Reviewed Original ResearchGestational trophoblastic diseasePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastTrophoblastic diseaseExaggerated placental site reactionChorionic villous trophoblastPlacental site noduleUnique clinical settingGestational choriocarcinomaSite reactionsMalignant tumorsLesional cellsProliferative lesionsProliferative disordersTrophoblastic cellsVillous trophoblastBiomarker expressionClinical settingImplantation sitesTumorsUnique genetic factorsRecent linkage studiesComplete hydatidiformPlacental Site Trophoblastic Tumor
Hui P. Placental Site Trophoblastic Tumor. Current Clinical Pathology 2011, 91-103. DOI: 10.1007/978-1-61779-394-3_6.Peer-Reviewed Original ResearchPlacental site trophoblastic tumorTrophoblastic tumorAtypical choriocarcinomaIntermediate trophoblastNeoplastic proliferationSimilar lesions
2010
Expression of glypican 3 in placental site trophoblastic tumor
Ou-Yang RJ, Hui P, Yang XJ, Zynger DL. Expression of glypican 3 in placental site trophoblastic tumor. Diagnostic Pathology 2010, 5: 64. PMID: 20868507, PMCID: PMC2954974, DOI: 10.1186/1746-1596-5-64.Peer-Reviewed Original ResearchConceptsPlacental site trophoblastic tumorPlacental site noduleInvasive cervical squamous cell carcinomaCervical squamous cell carcinomaNon-trophoblastic tumorsSquamous cell carcinomaTrophoblastic tumorCell carcinomaCytoplasmic stainingRare gestational trophoblastic neoplasmDiagnostic markerGestational trophoblastic neoplasmsGestational trophoblastic diseaseUseful diagnostic markerNon-neoplastic tissuesMembrane-bound heparan sulfate proteoglycanEndometrial adenocarcinomaUterine tumorsIntermediate trophoblastTrophoblastic diseaseTrophoblastic neoplasmsImmunohistochemical expressionHepatocellular carcinomaImmunohistochemical markersResultsEighty percent
2004
Comparative genomic hybridization study of placental site trophoblastic tumour: a report of four cases
Hui P, Riba A, Pejovic T, Johnson T, Baergen RN, Ward D. Comparative genomic hybridization study of placental site trophoblastic tumour: a report of four cases. Modern Pathology 2004, 17: 248-251. PMID: 14657956, DOI: 10.1038/modpathol.3800025.Peer-Reviewed Original ResearchConceptsPlacental site trophoblastic tumorTrophoblastic tumorChromosomal gainsCases of PSTTComparative genomic hybridizationClinicopathological studyComparative genomic hybridization studyIntermediate trophoblastCase reportNeoplastic proliferationSmall seriesAdditional studiesPathobiological significanceRecurrent chromosomal gainsChromosomal alterationsTumorsChromosomal lossGenomic hybridizationHybridization studiesReport