2024
Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody–drug conjugate, demonstrates in vitro and in vivo antitumor activity against primary and metastatic ovarian tumors overexpressing HER2
Mutlu L, McNamara B, Bellone S, Manavella D, Demirkiran C, Greenman M, Verzosa M, Buza N, Hui P, Hartwich T, Harold J, Yang-Hartwich Y, Zipponi M, Altwerger G, Ratner E, Huang G, Clark M, Andikyan V, Azodi M, Schwartz P, Santin A. Trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody–drug conjugate, demonstrates in vitro and in vivo antitumor activity against primary and metastatic ovarian tumors overexpressing HER2. Clinical & Experimental Metastasis 2024, 41: 765-775. PMID: 38909139, DOI: 10.1007/s10585-024-10297-z.Peer-Reviewed Original ResearchHigh-grade serous ovarian cancerClear cell carcinomaHER2-targeting antibody-drug conjugateAntibody-drug conjugatesT-DXdReceptor over-expressionTrastuzumab deruxtecanXenograft modelCell linesOvarian clear cell carcinomaOvarian cancer cell linesTumors overexpressing HER2Biologically aggressive tumorsFluorescence in situ hybridization assaySerous ovarian cancerEffective antibody-drug conjugatesIn vivo antitumor activityMouse xenograft modelMetastatic cell linesDS-8201aCancer cell linesAggressive tumorsHER2 expressionCell carcinomaOvarian cancer
2023
TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study
Wadia R, McHenry A, Abi-Raad R, Hui P. TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study. International Journal Of Gynecological Pathology 2023, 42: 555-560. PMID: 37255422, DOI: 10.1097/pgp.0000000000000961.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaInvasive squamous cell carcinomaVulvar intraepithelial neoplasiaCell carcinomaIntraepithelial neoplasiaLichen sclerosusAssociated with high-risk human papillomavirus infectionHigh-risk human papillomavirus infectionDifferentiated vulvar intraepithelial neoplasiaPresence of lymphovascular invasionInguinal lymph node metastasisHuman papillomavirus infectionVulvar lichen sclerosusMucin-producing carcinomaLymph node metastasisIntraepithelial lesionsLymphovascular invasionTP53 mutationsNode metastasisPapillomavirus infectionNeoplastic componentsCarcinomaUnique caseTP53Sclerosus
2021
Miscellaneous Neoplasia of the Ovary
Hui P, Banet N. Miscellaneous Neoplasia of the Ovary. Practical Anatomic Pathology 2021, 283-295. DOI: 10.1007/978-3-030-68608-6_11.Peer-Reviewed Original ResearchMetastatic carcinomaOvarian malignant epithelial tumorsPrimary ovarian lymphomaUnknown cell originSmall cell carcinomaBilateral ovarian involvementPrimary ovarian carcinomasMalignant epithelial tumorsLow-grade appearanceBreast primaryOvarian lymphomaStromal luteinizationOvarian involvementTumor thrombusCell carcinomaOvarian tumorsPrimary carcinomaAggressive tumorsCystic appearanceHypercalcemic typeMetastatic tumorsOvarian carcinomaTumor nodulesEpithelial tumorsCarcinomaNon-HPV-Associated Cervical Neoplasia
Quddus M, Ou J, Hui P. Non-HPV-Associated Cervical Neoplasia. Practical Anatomic Pathology 2021, 95-111. DOI: 10.1007/978-3-030-68608-6_4.Peer-Reviewed Original ResearchCervical adenocarcinomaHigh-risk human papilloma virusDaily practiceGestational trophoblastic tumorsHuman papilloma virusSquamous cell carcinomaUterine cervical carcinomaBiopsy/resectionTrophoblastic tumorCervical neoplasiaCell carcinomaCervical carcinomaDiagnostic challengeMetastatic tumorsPapilloma virusMalignant melanomaBenign lesionsTumorsHrHPVAdenocarcinomaCarcinomaSignificant percentagePathologistsHPVResectionUterine Epithelial Neoplasia
Hui P, Flynn C, Quddus M. Uterine Epithelial Neoplasia. Practical Anatomic Pathology 2021, 113-130. DOI: 10.1007/978-3-030-68608-6_5.Peer-Reviewed Original ResearchCommon endometrioid adenocarcinomaClear cell carcinomaHigh-grade carcinomaGestational alterationsEndometrial malignancyCurettage specimenEndometrial hyperplasiaEndometrial polypsEndometrial cancerEndometrioid adenocarcinomaHistological typeAtypical hyperplasiaCell carcinomaDedifferentiated carcinomaMixed carcinomasNeuroendocrine carcinomaNonneoplastic lesionsPreneoplastic conditionsInflammatory processPrognostic informationUndifferentiated carcinomaEpithelial neoplasiaSmall biopsiesCarcinomaMolecular classification
2018
Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation
Wu X, Snir O, Rottmann D, Wong S, Buza N, Hui P. Minimal microsatellite shift in microsatellite instability high endometrial cancer: a significant pitfall in diagnostic interpretation. Modern Pathology 2018, 32: 650-658. PMID: 30443012, DOI: 10.1038/s41379-018-0179-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkers, TumorColorectal Neoplasms, Hereditary NonpolyposisDNA-Binding ProteinsEndometrial NeoplasmsFemaleGenetic LociGenetic Predisposition to DiseaseHumansImmunohistochemistryMicrosatellite InstabilityMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinPhenotypePolymerase Chain ReactionPredictive Value of TestsReproducibility of ResultsConceptsEndometrial cancerMLH1/PMS2Endometrial carcinomaMSH6 lossMicrosatellite shiftCancer cohortMismatch repair deficiency testingMicrosatellite instability-high colorectal cancerEndometrial cancer cohortLoss of PMS2Clear cell carcinomaColorectal cancer cohortHigh colorectal cancerLynch syndrome familiesMSH2/MSH6PMS2 lossCell carcinomaColorectal cancerDeficiency testingSolid malignanciesColorectal carcinomaCarcinomaCancerIsolated lossMSH-6
2017
Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix
Wong S, Hong W, Hui P, Buza N. Comprehensive Analysis of PAX8 Expression in Epithelial Malignancies of the Uterine Cervix. International Journal Of Gynecological Pathology 2017, 36: 101-106. PMID: 27362905, DOI: 10.1097/pgp.0000000000000309.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaEpithelial malignanciesPAX8 expressionAdenosquamous carcinomaMajority of SCCsCervical squamous cell carcinomaPossible primary sitesEndometrioid-type tumorsWeak nuclear stainingTissue microarray slidesGynecologic malignanciesEndometrial adenocarcinomaEndometrioid adenocarcinomaMetastatic lesionsEndometrial carcinomaMetastatic sitesUterine cervixCell carcinomaCervical tumorsEndocervical adenocarcinomaDifferential diagnosisPrimary siteAdenocarcinomaCarcinomaMalignancy
2011
Tumor-Like Trophoblastic Conditions
Hui P. Tumor-Like Trophoblastic Conditions. Current Clinical Pathology 2011, 147-159. DOI: 10.1007/978-1-61779-394-3_10.Peer-Reviewed Original ResearchPlacental site nodulePlacental site trophoblastic tumorEpithelioid trophoblastic tumorTrophoblastic tumorIntermediate trophoblastExaggerated placental site reactionNon-trophoblastic neoplasmsSquamous cell carcinomaPrior pregnancyCell carcinomaSite reactionsIncidental findingProliferative lesionsNeoplastic counterpartsImplantation sitesCytological featuresLesionsTumorsTrophoblastConcurrent gestationReactive conditionsClinicopathologicallyPregnancyReactive processCarcinoma
2010
Endometrial Epithelial Neoplasms
Chhieng D, Hui P. Endometrial Epithelial Neoplasms. Current Clinical Pathology 2010, 87-105. DOI: 10.1007/978-1-60761-164-6_6.Peer-Reviewed Original ResearchCell carcinomaCommon endometrioid adenocarcinomaSquamous cell carcinomaTransitional cell carcinomaClear cell carcinomaHigh-grade carcinomaGestational alterationsEndometrial malignancyCurettage specimenEndometrial hyperplasiaEndometrial polypsEndometrioid adenocarcinomaHistological typeMucinous carcinomaMucinous componentAtypical hyperplasiaEndometrioid carcinomaMixed carcinomasNonneoplastic lesionsPreneoplastic conditionsInflammatory processUndifferentiated carcinomaEpithelial neoplasmsCarcinomaSmall biopsiesSquamous Lesions of the Cervix
Chhieng D, Hui P. Squamous Lesions of the Cervix. Current Clinical Pathology 2010, 35-58. DOI: 10.1007/978-1-60761-164-6_3.Peer-Reviewed Original ResearchSquamous cell carcinomaCell carcinomaHPV infectionHigh-risk HPV infectionCervical intraepithelial neoplasia (CIN) 1Low-risk HPV subtypesLow-risk subtypesHigh-grade CINHigh-risk HPVHuman papillomavirus infectionLow-risk groupClear cell carcinomaMinimal deviation adenocarcinomaSquamous papillomaHPV subtypesPapillomavirus infectionAdenosquamous carcinomaCondyloma acuminatumMucinous carcinomaSerous carcinomaSquamous lesionsCervical adenocarcinomaEndometrioid carcinomaNeuroendocrine carcinomaEndocervical adenocarcinomaLesions of the Vulva and Vagina
Chhieng D, Hui P. Lesions of the Vulva and Vagina. Current Clinical Pathology 2010, 15-34. DOI: 10.1007/978-1-60761-164-6_2.Peer-Reviewed Original ResearchSquamous cell carcinomaCell carcinomaPrimary clear cell carcinomaVulvar squamous cell carcinomaLow-risk HPV subtypesIntrauterine DES exposureHigh-risk HPVExtramammary Paget's diseaseMalignant mesenchymal tumorSquamous intraepithelial neoplasiaCommon primary malignancyClear cell carcinomaPreinvasive conditionsVulvar cancerHPV subtypesPrimary malignancyDES exposureLichen sclerosusIntraepithelial neoplasiaPaget's diseaseSquamous carcinomaWidespread metastasesAggressive angiomyxomaCondyloma acuminatumMesenchymal tumorsExpression of glypican 3 in placental site trophoblastic tumor
Ou-Yang RJ, Hui P, Yang XJ, Zynger DL. Expression of glypican 3 in placental site trophoblastic tumor. Diagnostic Pathology 2010, 5: 64. PMID: 20868507, PMCID: PMC2954974, DOI: 10.1186/1746-1596-5-64.Peer-Reviewed Original ResearchConceptsPlacental site trophoblastic tumorPlacental site noduleInvasive cervical squamous cell carcinomaCervical squamous cell carcinomaNon-trophoblastic tumorsSquamous cell carcinomaTrophoblastic tumorCell carcinomaCytoplasmic stainingRare gestational trophoblastic neoplasmDiagnostic markerGestational trophoblastic neoplasmsGestational trophoblastic diseaseUseful diagnostic markerNon-neoplastic tissuesMembrane-bound heparan sulfate proteoglycanEndometrial adenocarcinomaUterine tumorsIntermediate trophoblastTrophoblastic diseaseTrophoblastic neoplasmsImmunohistochemical expressionHepatocellular carcinomaImmunohistochemical markersResultsEighty percent