2020
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Pierce CA, Preston-Hurlburt P, Dai Y, Aschner CB, Cheshenko N, Galen B, Garforth SJ, Herrera NG, Jangra RK, Morano NC, Orner E, Sy S, Chandran K, Dziura J, Almo SC, Ring A, Keller MJ, Herold KC, Herold BC. Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients. Science Translational Medicine 2020, 12: eabd5487. PMID: 32958614, PMCID: PMC7658796, DOI: 10.1126/scitranslmed.abd5487.Peer-Reviewed Original ResearchConceptsImmune responsePediatric patientsAntibody titersAdult patientsSerum concentrationsT cellsSevere acute respiratory syndrome coronavirus 2IFN-γ serum concentrationsAcute respiratory syndrome coronavirus 2Robust T cell responsesSARS-CoV-2 infectionAntibody-dependent cellular phagocytosisRespiratory syndrome coronavirus 2Frequency of IFNMultisystem inflammatory syndromeT cell responsesCellular immune responsesSyndrome coronavirus 2Adaptive immune responsesAntiviral immune responseTumor necrosis factorMetropolitan hospital systemCoronavirus disease 2019COVID-19Age-dependent factors
2016
Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus–Herpes Simplex Virus Coinfection
Mesquita PM, Preston-Hurlburt P, Keller MJ, Vudattu N, Espinoza L, Altrich M, Anastos K, Herold KC, Herold BC. Role of Interleukin 32 in Human Immunodeficiency Virus Reactivation and Its Link to Human Immunodeficiency Virus–Herpes Simplex Virus Coinfection. The Journal Of Infectious Diseases 2016, 215: 614-622. PMID: 28007920, PMCID: PMC5388286, DOI: 10.1093/infdis/jiw612.Peer-Reviewed Original ResearchMeSH KeywordsAdultCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoinfectionCore Binding Factor Alpha 2 SubunitCross-Sectional StudiesDNA, ViralFemaleHerpes GenitalisHerpesvirus 2, HumanHIV InfectionsHIV-1HumansInterleukinsLeukocytes, MononuclearMiddle AgedRecombinant ProteinsRNA, ViralViral LoadYoung AdultConceptsHuman immunodeficiency virus type 1T cellsIL-32HSV-2HIV reactivationHIV reservoirHIV DNACell-associated HIV DNAHuman Immunodeficiency Virus ReactivationHerpes simplex virus type 2Peripheral blood mononuclear cellsSimplex virus type 2Immunodeficiency virus type 1Frequency of CCR5Higher HIV DNARecombinant IL-32γSystemic T cellsRUNX1 inhibitorT-cell phenotypeBlood mononuclear cellsSubpopulation of CD4Virus type 1Virus type 2Interleukin-32γAntiretroviral therapy
2012
Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple Myeloma
Waldron-Lynch F, Inzucchi SE, Menard L, Tai N, Preston-Hurlburt P, Hui P, McClaskey J, Hagopian WA, Meffre E, Marks PW, Wen L, Herold KC. Relapsing and Remitting Severe Hypoglycemia due to a Monoclonal Anti-insulin Antibody Heralding a Case of Multiple Myeloma. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 4317-4323. PMID: 23074233, PMCID: PMC3513536, DOI: 10.1210/jc.2012-2388.Peer-Reviewed Original ResearchConceptsInsulin autoimmune syndromeAnti-insulin antibodiesMonoclonal anti-insulin antibodiesMultiple myelomaPathogenic antibodiesCases of MMSelf-reactive clonesPrimary multiple myelomaSynchronized courseHepatitis C.Autoimmune syndromeClinical courseSevere hypoglycemiaAntibody subtypesMonoclonal gammopathyPatientsAntibodiesNovel caseHypoglycemiaMyelomaAffinity maturationLongitudinal case historiesLaboratory investigationsTreatmentLow affinity