1999
A diffusion barrier maintains distribution of membrane proteins in polarized neurons
Winckler B, Forscher P, Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 1999, 397: 698-701. PMID: 10067893, DOI: 10.1038/17806.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsAxonsBiological TransportCell CompartmentationCell MembraneCell PolarityCells, CulturedCytoskeletonDiffusionDimethyl SulfoxideLeukocyte L1 Antigen ComplexMembrane GlycoproteinsMembrane ProteinsMicrospheresNeural Cell Adhesion MoleculesNeuronsRatsReceptors, AMPAThy-1 AntigensConceptsMembrane proteinsDiffusion barrierObvious physical barriersPlasma membrane domainsLateral mobilityOptical tweezersCell-cell contactMembrane domainsPresumptive domainPolarized neuronsPlasma membraneCytoskeletal componentsPolarized distributionF-actinDiffusion of proteinsDistinct domainsBasolateral surfaceMembrane markersProteinSpecialized domainsInitial segmentTight junctionsAsymmetric distributionPhysical barrierTweezers
1992
Novel form of growth cone motility involving site-directed actin filament assembly
Forscher P, Lin C, Thompson C. Novel form of growth cone motility involving site-directed actin filament assembly. Nature 1992, 357: 515-518. PMID: 1608453, DOI: 10.1038/357515a0.Peer-Reviewed Original ResearchConceptsActin filament assemblyFilament assemblyNeuronal growth conesCortical F-actin networkMembrane-cytoskeletal interfaceF-actin assemblyF-actin networkGrowth conesGrowth cone migrationGrowth cone motilityExtracellular signalsBacterial parasiteMembrane proteinsCell movementCytoskeletal structuresIntracellular movementDevelopmental processesBead movementCell locomotionCone migrationMorphogenic changesMotile cellsAxonal guidanceCone motilityCellular mechanisms