2008
Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth
Schaefer AW, Schoonderwoert VT, Ji L, Mederios N, Danuser G, Forscher P. Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth. Developmental Cell 2008, 15: 146-162. PMID: 18606148, PMCID: PMC2595147, DOI: 10.1016/j.devcel.2008.05.003.Peer-Reviewed Original ResearchConceptsRetrograde actin network flowActin network flowNeurite outgrowthMyosin II contractilityRho-kinaseCell adhesion substratesCytoskeletal dynamicsMicrotubule behaviorAdhesion sitesAdhesion substrateMicrotubule dynamicsMyosin IIActin filamentsMolecular eventsGrowth responseMicrotubule movementKinaseNeuronal growthMicrotubulesOutgrowthGrowth cone neckGrowthOrganellesRegulationCascade
1998
Binding of Protein Kinase C Isoforms to Actin in Aplysia
Nakhost A, Forscher P, Sossin W. Binding of Protein Kinase C Isoforms to Actin in Aplysia. Journal Of Neurochemistry 1998, 71: 1221-1231. PMID: 9721748, DOI: 10.1046/j.1471-4159.1998.71031221.x.Peer-Reviewed Original ResearchConceptsPKC Apl IIProtein kinase C isoformsActin filamentsTriton-insoluble fractionApl IIF-actinCytoskeletal dynamicsC isoformsPhorbol ester-dependent mannerPKC Apl IMarine mollusk Aplysia californicaPhorbol ester treatmentNeuronal growth conesMollusk Aplysia californicaPKC phosphorylationApl IPKC-epsilonPhysiological roleIndependent PKCStriking colocalizationPKC inhibitorKinasePKC betaIIEster treatmentPKCAn emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance
Suter D, Forscher P. An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance. Current Opinion In Neurobiology 1998, 8: 106-116. PMID: 9568398, DOI: 10.1016/s0959-4388(98)80014-7.Peer-Reviewed Original ResearchConceptsGrowth cone guidanceCell adhesion moleculeCell surface receptorsAdhesion moleculesCytoskeletal dynamicsCytoskeletal networkCytoskeletal proteinsExtracellular substratesSurface receptorsConcerted actionMolecular motorsNeuronal growthImportant mechanismRecent studiesModulation of couplingProtein
1994
Cytoskeletal reorganization underlying growth cone motility
Lin C, Thompson C, Forscher P. Cytoskeletal reorganization underlying growth cone motility. Current Opinion In Neurobiology 1994, 4: 640-647. PMID: 7849519, DOI: 10.1016/0959-4388(94)90004-3.Peer-Reviewed Original ResearchConceptsIndividual cytoskeletal elementsGrowth cone motilityCytoskeletal dynamicsCytoskeletal reorganizationIntracellular cytoskeletonExtracellular substratesCytoskeletal elementsLiving cellsCone motilityNeuronal migrationNeuronal outgrowthFunctional couplingRecent studiesCytoskeletonImportant componentRegulation
1989
Calcium and polyphosphoinositide control of cytoskeletal dynamics
Forscher P. Calcium and polyphosphoinositide control of cytoskeletal dynamics. Trends In Neurosciences 1989, 12: 468-474. PMID: 2479150, DOI: 10.1016/0166-2236(89)90098-2.Peer-Reviewed Original ResearchConceptsMajor actin-binding proteinActin-binding proteinsNeuronal cell typesCytoskeletal dynamicsCytoskeletal plasticityCytoskeletal proteinsRegulatory proteinsActin polymerizationNeuronal motilityActin filamentsMembrane interactionsCell typesNeuronal cytoskeletonProteinReceptor-mediated changesPolyphosphoinositide turnoverSynaptic functionDynamic alterationsMechanochemical propertiesAxonal growthPhosphoinositide turnoverCell structureRecent evidenceTurnoverIntracellular calcium