2001
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
Whitmarsh A, Kuan C, Kennedy N, Kelkar N, Haydar T, Mordes J, Appel M, Rossini A, Jones S, Flavell R, Rakic P, Davis R. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes & Development 2001, 15: 2421-2432. PMID: 11562351, PMCID: PMC312784, DOI: 10.1101/gad.922801.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsApoptosisCarrier ProteinsEnzyme ActivationJNK Mitogen-Activated Protein KinasesMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein KinasesNeuronsOxidative StressConceptsJIP1 scaffold proteinSignal transduction pathwaysScaffold proteinTransduction pathwaysMAP kinase signal transduction pathwayJNK activationStress-induced JNK activationKinase signal transduction pathwayC-Jun N-terminal kinase (JNK) signal transduction pathwayExposure of cellsHomologous recombinationEnvironmental stressPrimary hippocampal neuronsC-JunAnoxic stressJIP1ProteinPathwayJNKExcitotoxic stressHippocampal neuronsActivationGenesStressCritical component
1999
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
Kuan C, Yang D, Roy D, Davis R, Rakic P, Flavell R. The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development. Neuron 1999, 22: 667-676. PMID: 10230788, DOI: 10.1016/s0896-6273(00)80727-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBrainCalcium-Calmodulin-Dependent Protein KinasesCaspasesEmbryonic and Fetal DevelopmentEnzyme ActivationGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicJNK Mitogen-Activated Protein KinasesMiceMice, KnockoutMitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesNervous SystemProtein KinasesRhombencephalonConceptsNeural tube closureBrain developmentEmbryonic lethalDouble mutantKinase familyCompound mutantsProtein kinaseCaspase activationPrecocious degenerationJNK2 geneTube closureEarly brain developmentCell deathJNK1Different membersSpecific apoptosisApoptosisMutantsMutant miceJNK2JNK3Mutant forebrainSevere dysregulationFamilyKinase