2019
Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer
Verma A, Schwartz N, Cohen DJ, Boyan BD, Schwartz Z. Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal cancer. Steroids 2019, 152: 108498. PMID: 31539535, DOI: 10.1016/j.steroids.2019.108498.Peer-Reviewed Original ResearchConceptsSex hormone receptorsEstrogen receptorBreast cancerHormone receptorsCanonical estrogen receptorsAnti-estrogen therapyLoss of ERαSquamous cell carcinomaEstrogen receptor αHormone therapyPrognostic valueCell carcinomaPrognostic indicatorLaryngeal cancerPrognostic markerSex hormonesLSCC tumorsEstrogen signalingReceptor αTumor growthPathogenic markersEnhanced aggressionImportant modulatorERαCancer
2017
Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes
Schwartz N, Verma A, Muktipaty C, Bivens C, Schwartz Z, Boyan BD. Estradiol receptor profile and estrogen responsiveness in laryngeal cancer and clinical outcomes. Steroids 2017, 142: 34-42. PMID: 29274403, DOI: 10.1016/j.steroids.2017.11.012.Peer-Reviewed Original ResearchConceptsLaryngeal cancerReceptor profileCancer cellsLaryngeal cancer patientsAnti-apoptotic effectsSteroid hormone receptorsClassical nuclear receptorsCancer cell linesClinical outcomesAnti-apoptotic potentialCancer patientsLaryngeal tumorsTreatment modalitiesSex hormonesClinical characterizationIndividual patientsEstrogen responsivenessHormone responsivenessDifferent cancer cellsCancerDifferent cancer cell linesHormone receptorsAdverse effectsReceptorsMembrane ER
2013
17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36
Schwartz N, Chaudhri RA, Hadadi A, Schwartz Z, Boyan BD. 17Beta-Estradiol Promotes Aggressive Laryngeal Cancer Through Membrane-Associated Estrogen Receptor-Alpha 36. Discover Oncology 2013, 5: 22-32. PMID: 24081562, PMCID: PMC3947116, DOI: 10.1007/s12672-013-0161-y.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisCarcinogenesisCarcinomaCell ProliferationCell SurvivalDrug Resistance, NeoplasmEstradiolEstrogen Receptor alphaFemaleHeLa CellsHumansLaryngeal NeoplasmsLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMolecular Targeted TherapyNeoplasm StagingNeovascularization, PathologicPhospholipase DProtein IsoformsProtein Kinase CVascular Endothelial Growth Factor AConceptsLaryngeal cancerMembrane associated estrogen receptorsLymph node metastasisRole of E2Estrogen receptor alphaLaryngeal carcinoma cell lineSecondary sex organsChemotherapy-induced apoptosisAntiestrogen therapyNode metastasisCarcinoma cell linesLaryngeal tumorsEstrogen receptorReceptor alphaERα36Metastatic factorsSimilar associationCompelling evidenceCytoplasmic receptorsCancerTumor samplesAntiapoptotic effectNovel drugsClinical analysisE2 responsiveness