2017
Computed tomographic perfusion to Predict Response to Recanalization in ischemic stroke
Lansberg MG, Christensen S, Kemp S, Mlynash M, Mishra N, Federau C, Tsai JP, Kim S, Nogueria RG, Jovin T, Devlin TG, Akhtar N, Yavagal DR, Haussen D, Dehkharghani S, Bammer R, Straka M, Zaharchuk G, Marks MP, Albers GW, Investigators F. Computed tomographic perfusion to Predict Response to Recanalization in ischemic stroke. Annals Of Neurology 2017, 81: 849-856. PMID: 28486789, PMCID: PMC5521988, DOI: 10.1002/ana.24953.Peer-Reviewed Original ResearchConceptsBaseline CT perfusionSymptom onsetEndovascular therapyCT perfusionTomographic perfusionConsecutive acute stroke patientsSmall ischemic coreTarget mismatch profileMulticenter cohort studyAcute stroke patientsFavorable clinical responseSelection of patientsTarget mismatchRate of reperfusionCT perfusion studyMagnetic resonance imagingAnn NeurolCritical hypoperfusionEndovascular reperfusionClinical responseCohort studyIschemic strokeIschemic coreStroke patientsPatient population
2014
Comparison of Magnetic Resonance Imaging Mismatch Criteria to Select Patients for Endovascular Stroke Therapy
Mishra NK, Albers GW, Christensen S, Marks M, Hamilton S, Straka M, Liggins JT, Kemp S, Mlynash M, Bammer R, Lansberg MG. Comparison of Magnetic Resonance Imaging Mismatch Criteria to Select Patients for Endovascular Stroke Therapy. Stroke 2014, 45: 1369-1374. PMID: 24699054, PMCID: PMC4007191, DOI: 10.1161/strokeaha.114.004772.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCarotid Artery DiseasesCerebrovascular DisordersDiffusion Magnetic Resonance ImagingFemaleHumansInfarction, Middle Cerebral ArteryMagnetic Resonance AngiographyMaleMiddle AgedMultimodal ImagingPerfusion ImagingReperfusionSeverity of Illness IndexStrokeTreatment OutcomeConceptsFavorable clinical responseMRA-DWI mismatchClinical responseMagnetic resonance angiographyDay 30Endovascular stroke trialsPerfusion Imaging EvaluationHealth Stroke ScaleGood functional outcomeEndovascular stroke therapyPerfusion-diffusion mismatchPWI-DWI mismatchInternal carotid arteryDEFUSE 2Endovascular reperfusionM1 occlusionMismatch criteriaNIHSS scoreStroke ScalePatient selectionStroke therapyStroke trialsFunctional outcomeImaging evaluationVessel occlusion
2013
J. T. P. Liggins et al.
Liggins JT, Yoo AJ, Mishra NK, Wheeler HM, Straka M, Leslie‐Mazwi T, Chaudhry ZA, Kemp S, Mlynash M, Bammer R, Albers GW, Lansberg MG, Investigators D. J. T. P. Liggins et al. International Journal Of Stroke 2013, 10: 705-709. PMID: 24207136, PMCID: PMC4048330, DOI: 10.1111/ijs.12207.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingBrain IschemiaCohort StudiesDatabases, FactualDiffusion Magnetic Resonance ImagingFemaleFibrinolytic AgentsHumansLogistic ModelsMaleMiddle AgedMulticenter Studies as TopicOutcome Assessment, Health CareSeverity of Illness IndexStrokeTissue Plasminogen ActivatorTreatment OutcomeConceptsPoor functional outcomeDiffusion-weighted imaging scoreFunctional outcomeImaging scoresTherapy scoreClinical responseDiffusion-weighted imaging volumeModified Rankin Scale scoreAcute stroke interventionAcute ischemic strokePercentage of patientsPredictive scoring systemRankin Scale scorePredictors of outcomeCharacteristic curveDiffusion-Weighted ImagingIschemic strokeEndovascular therapyIndependent predictorsPatient ageStroke interventionEndovascular treatmentValidation cohortClinical variablesLesion volumeInfluence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
Mishra NK, Mandava P, Chen C, Grotta J, Lees KR, Kent TA, collaboration V. Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke. International Journal Of Stroke 2013, 9: 613-617. PMID: 24148895, DOI: 10.1111/ijs.12162.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorBaseline National InstitutesHealth Stroke ScaleNon-Caucasian patientsPlasminogen activatorStroke ScaleNational InstituteRace-EthnicityNon-thrombolysed patientsStroke III TrialRace-ethnicity groupsNeuroprotection trialsIII trialsDiabetes statusFunctional outcomeImproved outcomesPatientsNeurological disordersCaucasian populationDifferential responseEthnicity groupsOutcomesCaucasiansOddsTrialsThe Modified Graeb Score
Morgan TC, Dawson J, Spengler D, Lees KR, Aldrich C, Mishra NK, Lane K, Quinn TJ, Diener-West M, Weir CJ, Higgins P, Rafferty M, Kinsley K, Ziai W, Awad I, Walters MR, Hanley D. The Modified Graeb Score. Stroke 2013, 44: 635-641. PMID: 23370203, PMCID: PMC6800016, DOI: 10.1161/strokeaha.112.670653.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchiveGraeb scalePoor outcomeIVH volumeB studyModified Rankin ScaleIntraventricular hemorrhage volumeModified Graeb scoreRankin ScaleMGS scoresVISTA studyHemorrhage volumeGraeb scoreAccelerated ResolutionPrognostic validitySemiquantitative scaleClinical practiceClot lysis
2010
Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity
Mishra NK, Lyden P, Grotta JC, Lees KR. Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity. Stroke 2010, 41: 2612-2617. PMID: 20947852, DOI: 10.1161/strokeaha.110.589317.Peer-Reviewed Original ResearchConceptsRankin Scale score distributionBaseline stroke severityBaseline NIHSSAssociation of treatmentScale score distributionStroke severityOdds ratioModified Rankin scale score distributionCochran-MantelVirtual International Stroke Trials ArchiveBaseline National InstitutesConsistent functional improvementsHealth Stroke ScaleProportional odds logistic regression analysisClinical trial enrollmentLogistic regression analysisNeuroprotection trialsUntreated comparatorsStroke ScaleTrial enrollmentAdjusted outcomesThrombolysed patientsNonrandomized comparisonBaseline severityFunctional improvement