Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Misra S, Khan E, Lam T, Mazumder R, Gururangan K, Hickman L, Goswami V, Funaro M, Eldem E, Sansing L, Sico J, Quinn T, Liebeskind D, Montaner J, Kwan P, Mishra N. Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury. Neurology 2023, 101: e2243-e2256. PMID: 37550071, PMCID: PMC10727219, DOI: 10.1212/wnl.0000000000207749.Peer-Reviewed Original ResearchConceptsStandardized mean differencePoststroke epilepsyBrain injuryGenetic susceptibilityDisparate time pointsRisk of epileptogenesisLate-onset seizuresDevelopment of epilepsyBlood glucose levelsTraumatic brain injuryMean biomarker levelsIndividual genetic susceptibilityWeb of ScienceReported biomarkersPrimary outcomeEpileptogenic processBiofluid biomarkersBias assessmentBiomarker levelsCommon biological pathwaysEnrichment analysisGlucose levelsHigh riskPrognostic studiesEpilepsyPathophysiology, Diagnosis, Prognosis, and Prevention of Poststroke Epilepsy
Tanaka T, Ihara M, Fukuma K, Mishra N, Koepp M, Guekht A, Ikeda A. Pathophysiology, Diagnosis, Prognosis, and Prevention of Poststroke Epilepsy. Neurology 2024, 102: e209450. PMID: 38759128, PMCID: PMC11175639, DOI: 10.1212/wnl.0000000000209450.Peer-Reviewed Original ResearchConceptsPoststroke epileptogenesisPoststroke epilepsyStroke survivorsAssociated with high mortalityAttention of health policymakersBurden of stroke worldwideDiagnostic work-upRisk of seizuresRisk-scoring modelSurrogate outcome measuresCortical superficial siderosisPrevention of seizuresSecondary prevention of seizuresPrimary prophylaxisConcomitant medicationsEEG findingsAcute stroke treatmentRecurrence riskSeizure prophylaxisSuperficial siderosisAntiseizure medicationsCardiovascular riskTreatment strategiesEnrolling patientsTissue-based approach