Featured Publications
Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review
Misra S, Quinn T, Falcone G, Sharma V, de Havenon A, Zhao Y, Eldem E, French J, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review. European Journal Of Neurology 2023, 30: 1791-1800. PMID: 36912749, DOI: 10.1111/ene.15777.Peer-Reviewed Original ResearchConceptsPost-traumatic epilepsyPost-stroke epilepsyTraumatic brain injuryRisk of epilepsySystematic reviewSingle nucleotide polymorphismsBrain injuryOdds ratioRisk of PSERisk of PTEAcute brain injuryGenetic polymorphismsConfidence intervalsAssociation of SNPsQ-Genie toolPSE patientsLate seizuresHazard ratioStroke patientsTBI patientsPrespecified protocolStudy qualityCurrent evidenceEpilepsyPatientsOutcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's test
2013
Thrombolysis in Stroke Despite Contraindications or Warnings?
Frank B, Grotta JC, Alexandrov AV, Bluhmki E, Lyden P, Meretoja A, Mishra NK, Shuaib A, Wahlgren NG, Weimar C, Lees KR. Thrombolysis in Stroke Despite Contraindications or Warnings? Stroke 2013, 44: 727-733. PMID: 23391774, DOI: 10.1161/strokeaha.112.674622.Peer-Reviewed Original ResearchConceptsHealth Stroke ScoreAlteplase treatmentStroke ScoreOdds ratioBaseline National InstitutesIntravenous alteplase treatmentPretreatment National InstitutesSingle antiplatelet agentTrial selection criteriaAcute ischemic strokeIschemic stroke patientsProportional odds logistic regression analysisSubgroup of patientsAdjusted odds ratioCommon clinical situationsNational InstituteLogistic regression analysisInternational normalizedIntravenous thrombolysisOral anticoagulationPrior strokeComprehensive retrospective analysisIschemic strokeRankin ScaleUntreated patients
2011
Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus
Mishra NK, Ahmed N, Davalos A, Iversen HK, Melo T, Soinne L, Wahlgren N, Lees KR. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology 2011, 77: 1866-1872. PMID: 22094479, DOI: 10.1212/wnl.0b013e318238ee42.Peer-Reviewed Original ResearchConceptsNIH Stroke Scale scoreBaseline NIH Stroke Scale scoreConcomitant diabetes mellitusPrior strokeIschemic stroke patientsDiabetes mellitusThrombolytic therapyStroke patientsOdds ratioScale scoreAcute ischemic stroke patientsInfluence of DMOutcomes of patientsStroke Scale scoreRankin Scale scoreConfidence intervalsDistribution of mRSAlteplase treatmentProportional odds logistic regressionMRS outcomesThrombolysis outcomesPatientsHaenszel testEuropean approvalCochran-Mantel
2010
Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity
Mishra NK, Lyden P, Grotta JC, Lees KR. Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity. Stroke 2010, 41: 2612-2617. PMID: 20947852, DOI: 10.1161/strokeaha.110.589317.Peer-Reviewed Original ResearchConceptsRankin Scale score distributionBaseline stroke severityBaseline NIHSSAssociation of treatmentScale score distributionStroke severityOdds ratioModified Rankin scale score distributionCochran-MantelVirtual International Stroke Trials ArchiveBaseline National InstitutesConsistent functional improvementsHealth Stroke ScaleProportional odds logistic regression analysisClinical trial enrollmentLogistic regression analysisNeuroprotection trialsUntreated comparatorsStroke ScaleTrial enrollmentAdjusted outcomesThrombolysed patientsNonrandomized comparisonBaseline severityFunctional improvement
2009
Mismatch-Based Delayed Thrombolysis
Mishra NK, Albers GW, Davis SM, Donnan GA, Furlan AJ, Hacke W, Lees KR. Mismatch-Based Delayed Thrombolysis. Stroke 2009, 41: e25-e33. PMID: 19926836, DOI: 10.1161/strokeaha.109.566869.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntracerebral hemorrhageFavorable outcomeMismatch patientsSuccessful reperfusionStroke onsetClinical outcomesClinical benefitRecanalization/reperfusionPhase III trialsFavorable clinical outcomeWeb of KnowledgeDelayed thrombolysisMismatch selectionThrombolysis trialsIII trialsRelevant trialsCase seriesRoutine careThrombolytic therapyClinical findingsClinical trialsImproved outcomesOdds ratioPretreatment imaging