2024
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study
Rogne T, Wang R, Wang P, Deziel N, Metayer C, Wiemels J, Chen K, Warren J, Ma X. High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study. The Lancet Planetary Health 2024, 8: e506-e514. PMID: 38969477, PMCID: PMC11260908, DOI: 10.1016/s2542-5196(24)00121-9.Peer-Reviewed Original ResearchConceptsRisk of childhood acute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaLatino childrenNon-Latino white childrenAssociated with risk of adverse pregnancy outcomesCalifornia Cancer RegistryRisk of acute lymphoblastic leukemiaCalifornia birth recordsRisk of adverse pregnancy outcomesPre-pregnancy periodAssociated with riskBayesian meta-regressionNational Institutes of HealthCancer RegistryCases of childhood acute lymphoblastic leukemiaNational Center for Advancing Translational SciencesAdverse pregnancy outcomesAcute lymphoblastic leukemia casesInstitutes of HealthInvestigation of mechanistic pathwaysBirth recordsGestational weeks 8Pre-pregnancy
2023
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryResidential proximity to unconventional oil and gas development and birth defects in Ohio
Gaughan C, Sorrentino K, Liew Z, Johnson N, Clark C, Soriano M, Plano J, Plata D, Saiers J, Deziel N. Residential proximity to unconventional oil and gas development and birth defects in Ohio. Environmental Research 2023, 229: 115937. PMID: 37076028, PMCID: PMC10198955, DOI: 10.1016/j.envres.2023.115937.Peer-Reviewed Original ResearchConceptsNeural tube defectsCertain birth defectsBirth defectsOdds ratioRegistry-based cohort studyTube defectsConfidence intervalsResidential proximityState birth recordsBirth defect typeState surveillance systemsMaternal residential proximityLimb reduction defectsCohort studyUnexposed mothersStructural birth defectsLive birthsInfant sexBirth recordsSpina bifidaReduction defectsFemale offspringDevelopmental toxicantsExposure metrics
2022
Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017
Clark CJ, Johnson NP, Soriano M, Warren JL, Sorrentino KM, Kadan-Lottick NS, Saiers JE, Ma X, Deziel NC. Unconventional Oil and Gas Development Exposure and Risk of Childhood Acute Lymphoblastic Leukemia: A Case–Control Study in Pennsylvania, 2009–2017. Environmental Health Perspectives 2022, 130: 087001. PMID: 35975995, PMCID: PMC9383266, DOI: 10.1289/ehp11092.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaCase-control studyOdds ratioChildhood leukemiaLymphoblastic leukemiaPerinatal windowRegistry-based case-control studyChildhood acute lymphoblastic leukemiaConfidence intervalsResidential proximityChildren ages 2Risk factorsMaternal raceChild healthExposure windowsSocio-economic statusPotential associationLeukemiaLogistic regressionAge 2Birth yearCommon formBirth residenceDevelopment exposureOddsAssessing Exposure to Unconventional Oil and Gas Development: Strengths, Challenges, and Implications for Epidemiologic Research
Deziel NC, Clark CJ, Casey JA, Bell ML, Plata DL, Saiers JE. Assessing Exposure to Unconventional Oil and Gas Development: Strengths, Challenges, and Implications for Epidemiologic Research. Current Environmental Health Reports 2022, 9: 436-450. PMID: 35522388, PMCID: PMC9363472, DOI: 10.1007/s40572-022-00358-4.Peer-Reviewed Original ResearchPrenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort
Luo J, Ramlau-Hansen CH, Kesmodel US, Xiao J, Vasiliou V, Deziel NC, Zhang Y, Olsen J, Liew Z. Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. Environmental Health Perspectives 2022, 130: 017006. PMID: 35080464, PMCID: PMC8791068, DOI: 10.1289/ehp9478.Peer-Reviewed Original ResearchConceptsDanish National Birth CohortMaternal alcohol intakePrenatal PFAS exposurePalpebral fissure lengthShorter palpebral fissure lengthNational Birth CohortYears of agePFAS exposureSecond tertileAlcohol intakePrenatal exposureOdds ratioBirth cohortSpecific neurologic deficitsConfidence intervalsFetal brain developmentSex-specific associationsNeurologic deficitsFirst trimesterPotential confoundersNeurodevelopmental effectsAlcohol exposureStratified analysisNormal groupMultinomial logistic regression
2020
Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California
Deziel N, Zhang Y, Wang R, Wiemels JL, Morimoto L, Clark CJ, Metayer C, Ma X. Birth Characteristics and Risk of Pediatric Thyroid Cancer: A Population-Based Record-Linkage Study in California. Thyroid 2020, 31: 596-606. PMID: 32912083, PMCID: PMC8195873, DOI: 10.1089/thy.2020.0217.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetBirth CertificatesBirth OrderBirth WeightCaliforniaCase-Control StudiesChildChild, PreschoolEducational StatusFemaleHispanic or LatinoHumansIncidenceInfantInfant, NewbornMaleRace FactorsRegistriesRisk AssessmentRisk FactorsSex FactorsThyroid NeoplasmsTime FactorsYoung AdultConceptsPediatric thyroid cancerHigh birth weightFollicular thyroid cancerThyroid cancerHigher birth orderBirth characteristicsRisk factorsHispanic ethnicityBirth weightOdds ratioFirst primary thyroid cancerPapillary thyroid cancer casesBirth orderMultivariable logistic regression modelSecond primary malignanciesLong-term therapyAdjusted odds ratioPopulation-based studyPrimary thyroid cancerRecord linkage studyConfidence intervalsImportant risk factorCancer registry dataCase-control studyThyroid cancer casesPrenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasmaAssessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls
Howland RE, Deziel NC, Bentley GR, Booth M, Choudhury OA, Hofmann JN, Hoover RN, Katki HA, Trabert B, Fox SD, Troisi R, Houghton LC. Assessing Endogenous and Exogenous Hormone Exposures and Breast Development in a Migrant Study of Bangladeshi and British Girls. International Journal Of Environmental Research And Public Health 2020, 17: 1185. PMID: 32069802, PMCID: PMC7068451, DOI: 10.3390/ijerph17041185.Peer-Reviewed Original ResearchConceptsEstrogen metabolitesBPA-glucuronideBreast developmentMigrant studiesBreast cancer incidenceEndogenous estrogen levelsBisphenol A (BPA) exposureExogenous hormone exposureCross-sectional studyBangladeshi girlsTime of interviewUrine spot samplesHazard ratioEstrogen levelsA ExposureCancer incidenceEarlier thelarcheTanner stageUbiquitous exposureHormone exposureThelarcheLiquid chromatography-tandem mass spectrometryConfidence intervalsWhite BritishAdolescent girls
2016
Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence
Elliott EG, Trinh P, Ma X, Leaderer BP, Ward MH, Deziel NC. Unconventional oil and gas development and risk of childhood leukemia: Assessing the evidence. The Science Of The Total Environment 2016, 576: 138-147. PMID: 27783932, PMCID: PMC6457992, DOI: 10.1016/j.scitotenv.2016.10.072.Peer-Reviewed Original ResearchConceptsWater contaminantsPotential water contaminantsMajority of compoundsWater pollutantsPolycyclic aromatic hydrocarbonsHydraulic fracturing fluidsPollutantsAromatic hydrocarbonsAir pollutantsU.S. Environmental Protection AgencyCompoundsEnvironmental Protection AgencyPotential air pollutantsPossible human carcinogenContaminantsChemicalsCarcinogenicity of compoundsLeukemia/lymphomaProtection AgencyChildhood leukemiaWaterButadieneBenzeneFracturing fluidOil
2015
Associations between self-reported pest treatments and pesticide concentrations in carpet dust
Deziel NC, Colt JS, Kent EE, Gunier RB, Reynolds P, Booth B, Metayer C, Ward MH. Associations between self-reported pest treatments and pesticide concentrations in carpet dust. Environmental Health 2015, 14: 27. PMID: 25889489, PMCID: PMC4374193, DOI: 10.1186/s12940-015-0015-x.Peer-Reviewed Original ResearchConceptsWeed treatmentsPest treatmentsPesticide concentrationsCarpet dust samplesPesticide active ingredientsAgricultural pesticide applicationsSelf-reported treatmentPesticide useResidential pesticide useTick treatmentPest typesPesticide applicationCypermethrin levelsHerbicide concentrationsPesticide categoriesGarden productsProfessional applicators
2014
Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia
Deziel NC, Rull RP, Colt JS, Reynolds P, Whitehead TP, Gunier RB, Month SR, Taggart DR, Buffler P, Ward MH, Metayer C. Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. Environmental Research 2014, 133: 388-395. PMID: 24948546, PMCID: PMC4119528, DOI: 10.1016/j.envres.2014.04.033.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaLymphoblastic leukemiaOdds ratioPopulation-based case-control studyDiagnosis/reference datePAH exposureRisk of childhoodConfidence intervalsCase-control studyResidential dustVacuum dustLog-transformed concentrationsLogistic regressionProbable human carcinogenHigh volume small surface samplerDemographic characteristicsResidential Levels of Polybrominated Diphenyl Ethers and Risk of Childhood Acute Lymphoblastic Leukemia in California
Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. Residential Levels of Polybrominated Diphenyl Ethers and Risk of Childhood Acute Lymphoblastic Leukemia in California. Environmental Health Perspectives 2014, 122: 1110-1116. PMID: 24911217, PMCID: PMC4181922, DOI: 10.1289/ehp.1307602.Peer-Reviewed Original ResearchConceptsOdds ratioChildhood acute lymphoblastic leukemiaBirth certificate controlsNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyYears of ageChildhood Leukemia StudyRace/ethnicityDate of birthLymphoblastic leukemiaLogistic regressionLeukemia StudyAdditional studiesHigh volume small surface samplerBDE-203House dustCommon PBDEsPositive associationBDE-207AssociationBiological measuresRiskBDE-99BDE-196