2020
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Lopez MG, Hughes CG, DeMatteo A, O’Neal J, McNeil JB, Shotwell MS, Morse J, Petracek MR, Shah AS, Brown NJ, Billings FT. Intraoperative Oxidative Damage and Delirium after Cardiac Surgery. Anesthesiology 2020, 132: 551-561. PMID: 31770146, PMCID: PMC7015795, DOI: 10.1097/aln.0000000000003016.Peer-Reviewed Original ResearchConceptsS100 calcium-binding protein BCalcium-binding protein BUbiquitin carboxyl-terminal hydrolase isozyme L1Blood-brain barrier disruptionNeuronal injuryPostoperative deliriumF2-isoprostanesBarrier disruptionOxidative damageConfusion Assessment MethodCardiac surgery patientsPostoperative day 1Intensive care unitBlood-brain barrierEnzyme-linked immunosorbentProtein BKidney injuryCohort studySurgery patientsCardiac surgeryTotal cohortCare unitIndependent associationClinical trialsPlasma concentrations
2018
Early urine electrolyte patterns in patients with acute heart failure
Collins SP, Jenkins CA, Baughman A, Miller KF, Storrow AB, Han JH, Brown NJ, Liu D, Luther JM, McNaughton CD, Self WH, Peng D, Testani JM, Lindenfeld J. Early urine electrolyte patterns in patients with acute heart failure. ESC Heart Failure 2018, 6: 80-88. PMID: 30295437, PMCID: PMC6351901, DOI: 10.1002/ehf2.12368.Peer-Reviewed Original ResearchConceptsAcute heart failureDiuretic administrationDiuretic resistanceHeart failureLoop diureticsLow urinary sodiumEscalation of therapyUrine sodium excretionSubset of patientsSystolic blood pressureEmergency department patientsUrine sodium concentrationAHF diagnosisAHF patientsIntravenous diureticsUrinary sodiumED staySodium excretionUrinary electrolytesUrine sodiumNatriuretic responseStandard therapyBlood pressureDepartment patientsUrine output
2016
Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition
Hubers SA, Brown NJ. Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition. Circulation 2016, 133: 1115-1124. PMID: 26976916, PMCID: PMC4800749, DOI: 10.1161/circulationaha.115.018622.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, Drug-InducedAminobutyratesAngioedemaAngiotensin Receptor AntagonistsBiphenyl CompoundsBradykininContraindicationsDrug CombinationsDrug CostsDrug SynergismEnalaprilEnzyme InhibitorsFemaleFollow-Up StudiesHeart FailureHumansHyperkalemiaHypertensionKidneyMulticenter Studies as TopicNatriuretic PeptidesNeprilysinPregnancyProdrugsProspective StudiesPyridinesRandomized Controlled Trials as TopicStroke VolumeTetrazolesThiazepinesValsartanConceptsValsartan/sacubitrilReduced ejection fractionHeart failureNatriuretic peptideEjection fractionN-terminal pro-brain natriuretic peptideNeprilysin inhibitor prodrug sacubitrilPro-brain natriuretic peptideAngiotensin receptor blocker valsartanAngiotensin receptor antagonismAngiotensin receptor blockersHeart Failure TrialReceptor blocker valsartanAngiotensin receptor antagonistsBrain natriuretic peptideOngoing clinical trialsMechanism of actionNeprilysin inhibitionAldosterone antagonistsAldosterone systemReceptor blockersBlood pressureFailure TrialPathophysiological mechanismsReceptor antagonism
2013
Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial
Wu JH, Marchioli R, Silletta MG, Macchia A, Song X, Siscovick DS, Harris WS, Masson S, Latini R, Albert C, Brown NJ, Lamarra M, Favaloro RR, Mozaffarian D. Plasma Phospholipid Omega‐3 Fatty Acids and Incidence of Postoperative Atrial Fibrillation in the OPERA Trial. Journal Of The American Heart Association 2013, 2: e000397. PMID: 24145742, PMCID: PMC3835252, DOI: 10.1161/jaha.113.000397.Peer-Reviewed Original ResearchConceptsFish oil supplementationMorning of surgeryPostoperative atrial fibrillationCardiac surgeryOil supplementationDocosapentaenoic acidAtrial fibrillationDocosahexaenoic acidEicosapentaenoic acidShort-term fish oil supplementationPUFA levelsOmega-3 fatty acidsCardiac surgery patientsPlasma phospholipid nPostoperative day 10Substantial interindividual variabilityOPERA trialPoAF episodesPlacebo supplementationPrimary endpointSecondary endpointsHospital dischargeSurgery patientsAntiarrhythmic potentialFatty acids
2011
Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology
Todd Tzanetos DR, Yu C, Hernanz-Schulman M, Barr FE, Brown NJ. Prospective study of the incidence and predictors of thrombus in children undergoing palliative surgery for single ventricle physiology. Intensive Care Medicine 2011, 38: 105-112. PMID: 21979273, PMCID: PMC4747610, DOI: 10.1007/s00134-011-2378-y.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCentral Nervous SystemChild, PreschoolFemaleHeart Defects, CongenitalHeart VentriclesHospitals, PediatricHumansInfantInfant, NewbornMaleMedical AuditPalliative CarePerioperative CarePostoperative ComplicationsPredictive Value of TestsProspective StudiesTennesseeThrombosisUltrasonographyConceptsSingle ventricle physiologyTissue plasminogen activator antigenCardiopulmonary bypass timePlasminogen activator antigenPlasma antithrombin IIIVentricle physiologyAntithrombin IIIBypass timePalliative surgeryVentricular functionTissue plasminogen activator antigen concentrationAortic cross-clamp timeCentral venous catheter daysLonger cardiopulmonary bypass timePoor preoperative ventricular functionPredictors of thrombusPreoperative ventricular functionChest tube outputCross-clamp timeBiomarkers of coagulationBlood product administrationLow antithrombin IIICentral venous systemIntensive care unitPlasminogen activator inhibitor-1
2010
Interactive Hemodynamic Effects of Dipeptidyl Peptidase-IV Inhibition and Angiotensin-Converting Enzyme Inhibition in Humans
Marney A, Kunchakarra S, Byrne L, Brown NJ. Interactive Hemodynamic Effects of Dipeptidyl Peptidase-IV Inhibition and Angiotensin-Converting Enzyme Inhibition in Humans. Hypertension 2010, 56: 728-733. PMID: 20679179, PMCID: PMC3305047, DOI: 10.1161/hypertensionaha.110.156554.Peer-Reviewed Original ResearchMeSH KeywordsAdultAldosteroneAngiotensin-Converting Enzyme InhibitorsBlood GlucoseBlood PressureDiabetes Mellitus, Type 2Dipeptidyl Peptidase 4Dose-Response Relationship, DrugDouble-Blind MethodDrug InteractionsDrug Therapy, CombinationEnalaprilFemaleHeart RateHemodynamicsHumansInsulinMaleMetabolic SyndromeMiddle AgedPeptidyl-Dipeptidase AProspective StudiesPyrazinesRenal CirculationSitagliptin PhosphateSodiumTriazolesConceptsDipeptidyl peptidase IV inhibitionACE inhibitionHypotensive responseHemodynamic effectsBlood pressureHeart rateSerum dipeptidyl peptidase IV activityAngiotensin-Converting Enzyme InhibitionAcute ACE inhibitionVasoconstrictor neuropeptide YBlood pressure responseRenal blood flowSympathetic nervous systemType 2 diabeticsCross-over fashionDipeptidyl peptidase IV inhibitorsDose-dependent effectDipeptidyl peptidase IV activityDose-dependent mannerPeptidase IV inhibitorsPeptidase IV activityMetabolic syndromeNorepinephrine concentrationsIncretin hormonesNeuropeptide Y
2009
Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery
Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry T, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman; D, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D. Variation in the 4q25 Chromosomal Locus Predicts Atrial Fibrillation After Coronary Artery Bypass Graft Surgery. Circulation Genomic And Precision Medicine 2009, 2: 499-506. PMID: 20031626, PMCID: PMC2801871, DOI: 10.1161/circgenetics.109.849075.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryArtery bypass graft surgeryPostoperative atrial fibrillationBypass graft surgeryGraft surgeryAtrial fibrillationSingle nucleotide polymorphismsValidation cohortDiscovery cohortCardiac surgery cohortConcurrent valve surgeryCommon adverse eventsCohort of patientsAdditive odds ratioMultiple comparisonsChromosome 4q25 variantsSurgery cohortValve surgeryAdverse eventsClinical predictorsAmbulatory populationOdds ratioClinical covariatesUS CentersMultivariate predictors
2007
Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass
Pretorius M, Donahue BS, Yu C, Greelish JP, Roden DM, Brown NJ. Plasminogen Activator Inhibitor-1 as a Predictor of Postoperative Atrial Fibrillation After Cardiopulmonary Bypass. Circulation 2007, 116: i-1-i-7. PMID: 17846288, DOI: 10.1161/circulationaha.106.677906.Peer-Reviewed Original ResearchConceptsPostoperative atrial fibrillationPAI-1 antigen concentrationsCardiopulmonary bypassAtrial fibrillationPlasminogen activator inhibitor-1Remote historyIndependent predictorsActivator inhibitor-1Antigen concentrationPAI-1Development of AFRisk of AFInhibitor-1Administration of protaminePreoperative PAI-1Elective cardiac surgeryTime of surgeryPAI-1 concentrationsBlood of patientsHospital stayValve surgeryAdult patientsYounger patientsCardiac surgerySignificant morbidity