2016
Na+ coordination at the Na2 site of the Na+/I− symporter
Ferrandino G, Nicola JP, Sánchez YE, Echeverria I, Liu Y, Amzel LM, Carrasco N. Na+ coordination at the Na2 site of the Na+/I− symporter. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e5379-e5388. PMID: 27562170, PMCID: PMC5027462, DOI: 10.1073/pnas.1607231113.Peer-Reviewed Original ResearchConceptsNa2 siteActive I(-) transportThyroid hormone biosynthesisSodium/iodide symporterSLC5 familyGreat medical relevanceSame foldPlasma membraneHormone biosynthesisDependent transportersSimilar functionsMedical relevanceTransportersMechanistic insightsWhole cellsBinding sitesResiduesSymporterI- transportS353Side chainsT354SitesBiosynthesisIons bind
1999
Escape from the Acute Wolff-Chaikoff Effect Is Associated with a Decrease in Thyroid Sodium/Iodide Symporter Messenger Ribonucleic Acid and Protein*
Eng P, Cardona G, Fang S, Previti M, Alex S, Carrasco N, Chin W, Braverman L. Escape from the Acute Wolff-Chaikoff Effect Is Associated with a Decrease in Thyroid Sodium/Iodide Symporter Messenger Ribonucleic Acid and Protein*. Endocrinology 1999, 140: 3404-3410. DOI: 10.1210/en.140.8.3404.Peer-Reviewed Original ResearchAcute Wolff-Chaikoff effectThyroid peroxidase mRNANIS mRNAIodide administrationWolff-Chaikoff effectThyroid peroxidaseIodide transportTSH receptorNIS proteinIodide ingestionIntrathyroidal iodine contentIodine-induced hypothyroidismSerum TSH levelsOrganification of iodideAcute experimentsIodide-induced changesMessenger ribonucleic acidPlasma iodide levelsTSH levelsHashimoto's thyroiditisChronic experimentsSerum T4Plasma iodide concentrationsSodium/iodide symporterCyclophilin mRNAEscape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein.
Eng P, Cardona G, Fang S, Previti M, Alex S, Carrasco N, Chin W, Braverman L. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology 1999, 140: 3404-10. PMID: 10433193, DOI: 10.1210/endo.140.8.6893.Peer-Reviewed Original ResearchConceptsAcute Wolff-Chaikoff effectThyroid peroxidase mRNANIS mRNAIodide administrationWolff-Chaikoff effectThyroid peroxidaseIodide transportTSH receptorNIS proteinIodide ingestionIntrathyroidal iodine contentIodine-induced hypothyroidismSerum TSH levelsOrganification of iodideAcute experimentsIodide-induced changesMessenger ribonucleic acidPlasma iodide levelsTSH levelsHashimoto's thyroiditisChronic experimentsSerum T4Plasma iodide concentrationsSodium/iodide symporterHormone measurements