2022
Noninvasive amino acid turnover predicts human embryo aneuploidy
Olcay IO, Akcay B, Bahceci M, Arici A, Boynukalin K, Yakicier C, Ozpinar A, Basar M. Noninvasive amino acid turnover predicts human embryo aneuploidy. Gynecological Endocrinology 2022, 38: 461-466. PMID: 35481385, DOI: 10.1080/09513590.2022.2068520.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAneuploidyBlastocystEmbryo Culture TechniquesEmbryo ImplantationFemaleGenetic TestingHumansPregnancyPreimplantation DiagnosisConceptsEuploid groupAneuploid groupAmino acid turnoverAneuploid embryosHigher implantation rateAmino acid metabolism profilePotential diagnostic testPreimplantation genetic testingAcid turnoverBlank control groupEmbryo selection criteriaAssisted reproduction technologyMultiple pregnanciesImplantation ratePatient groupAmino acid concentrationsAneuploid blastocystsEmbryo aneuploidyControl groupDay 5IVF clinicsLow success rateGenetic testingCulture mediumTE biopsy
2014
Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro
Basar M, Bozkurt I, Guzeloglu-Kayisli O, Sozen B, Tekmen I, Schatz F, Arici A, Lockwood CJ, Kayisli UA. Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro. Fertility And Sterility 2014, 102: 1777-1784. PMID: 25305729, DOI: 10.1016/j.fertnstert.2014.09.004.Peer-Reviewed Original ResearchConceptsUnfolded protein responseProtein responseBlastocyst formationEmbryo developmentActivation of UPRPreimplantation embryo developmentTM treatmentBlastocyst developmentEffect of tunicamycinEndoplasmic reticulum stressEmbryonic developmentER stressCell embryosNuclear fragmentationMorphological differencesImmunoglobulin proteinBlastocyst stageReticulum stressTunicamycinDevelopment ratePregnant mare serum gonadotropinBlastocyst development rateProtein-1 mRNA expressionNongenomic mechanismsEmbryos