Moein Rajaei, PhD
Postdoctoral AssociateAbout
Research
Publications
2024
Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred Caenorhabditis elegans mutation accumulation lines.
Crombie TA, Rajaei M, Saxena AS, Johnson LM, Saber S, Tanny RE, Ponciano JM, Andersen EC, Zhou J, Baer CF. Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred Caenorhabditis elegans mutation accumulation lines. Genetics 2024, 228 PMID: 39139098, DOI: 10.1093/genetics/iyae136.Peer-Reviewed Original ResearchTracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery.
Liu M, Jin S, Agabiti SS, Jensen TB, Yang T, Radda JSD, Ruiz CF, Baldissera G, Rajaei M, Townsend JP, Muzumdar MD, Wang S. Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery. BioRxiv 2024 PMID: 37546882, DOI: 10.1101/2023.07.23.550157.Peer-Reviewed Original ResearchPerioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer
Cecchini M, Salem R, Robert M, Czerniak S, Blaha O, Zelterman D, Rajaei M, Townsend J, Cai G, Chowdhury S, Yugawa D, Tseng R, Arbelaez C, Jiao J, Shroyer K, Thumar J, Kortmansky J, Zaheer W, Fischbach N, Persico J, Stein S, Khan S, Cha C, Billingsley K, Kunstman J, Johung K, Wiess C, Muzumdar M, Spickard E, Aushev V, Laliotis G, Jurdi A, Liu M, Escobar-Hoyos L, Lacy J. Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer. JAMA Oncology 2024, 10: 1027-1035. PMID: 38900452, PMCID: PMC11190830, DOI: 10.1001/jamaoncol.2024.1575.Peer-Reviewed Original ResearchProgression-free survivalPancreatic ductal adenocarcinomaOverall survivalCtDNA levelsPhase 2 nonrandomized controlled trialAnalysis of circulating tumor DNAMedian progression-free survivalResectable pancreatic ductal adenocarcinomaControlled trialsAssess surgical candidacyBaseline ctDNA levelModified 5-fluorouracilResectable pancreatic cancerPancreatic protocol computed tomographyAssociated with recurrenceTumor molecular featuresAggressive malignant tumorKaplan-Meier estimatesRandomized clinical trialsStandard of careCtDNA-positivePreoperative cyclesNonrandomized controlled trialsUnresectable diseaseModified FOLFIRINOX
2023
Characterization of GATA3 and Mammaglobin in breast tumors from African American Women.
Ricks-Santi LJ, Fredenburg K, Rajaei M, Esnakula A, Naab T, McDonald JT, Kanaan Y. Characterization of GATA3 and Mammaglobin in breast tumors from African American Women. Arch Microbiol Immunol 2023, 7: 18-28. PMID: 37383682, DOI: 10.26502/ami.936500101.Peer-Reviewed Original Research
2022
Mutation, selection, and the prevalence of the Caenorhabditis elegans heat-sensitive mortal germline phenotype.
Saber S, Snyder M, Rajaei M, Baer CF. Mutation, selection, and the prevalence of the Caenorhabditis elegans heat-sensitive mortal germline phenotype. G3 (Bethesda) 2022, 12 PMID: 35311992, DOI: 10.1093/g3journal/jkac063.Peer-Reviewed Original Research
2021
Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans.
Rajaei M, Saxena AS, Johnson LM, Snyder MC, Crombie TA, Tanny RE, Andersen EC, Joyner-Matos J, Baer CF. Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans. Genome Res 2021, 31: 1602-1613. PMID: 34404692, DOI: 10.1101/gr.275372.121.Peer-Reviewed Original Research
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