2015
PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates
Hillmer AT, Zheng MQ, Li S, Scheunemann M, Lin SF, Holden D, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Carson RE, Brust P, Huang Y. PET imaging evaluation of [18F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2015, 43: 537-547. PMID: 26455500, PMCID: PMC4733418, DOI: 10.1007/s00259-015-3209-0.Peer-Reviewed Original ResearchConceptsPurposePositron emission tomographyDose-dependent blockadeStandardized uptake valueΑ7 nicotinic acetylcholine receptorNonhuman primatesPeak standardized uptake valueBaseline PET scanParent fractionEx vivo analysisPlasma free fractionNicotinic acetylcholine receptorsTotal distribution volumeBrain tissue samplesRegional rank orderTwo-tissue compartment modelSpecific radioligandFrontal cortexOccipital cortexNovel radioligandPET scansArterial plasmaAcetylcholine receptorsUptake valueAlzheimer's diseaseBrain tissue
2010
Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination?
Huang Y, Zheng MQ, Gerdes JM. Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination? Current Topics In Medicinal Chemistry 2010, 10: 1499-526. PMID: 20583995, DOI: 10.2174/156802610793176792.Peer-Reviewed Original ResearchConceptsChemical scaffoldsPositron emission tomographySerotonin transporterTwenty-year journeyImaging tracerFunction of SERTRelated compoundsNon-specific bindingSingle photon emissionRadiotracer developmentSpecific binding signalsPromising radiotracerAlzheimer's diseaseEmission tomographyNeurodegenerative disordersNeuropsychiatric disordersSPECT radiotracerSubstance abusePharmacological propertiesDiseaseScaffoldsTerms of tissueSPECTDiarylsulfidesVivo