Ming Lu, MD
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Yale Co-Authors
Frequent collaborators of Ming Lu's published research.
Publications Timeline
A big-picture view of Ming Lu's research output by year.
Emile Boulpaep, MD
Tong Wang, MD
Ke Dong, MD, MS
Michael Caplan, PhD, MD
William C. Sessa, PhD
32Publications
1,404Citations
Publications
2019
A non-enzymatic method for dissection of mouse bladder urothelial tissue.
Lu M, Zhu K, Schulam PG, Chai TC. A non-enzymatic method for dissection of mouse bladder urothelial tissue. Nature Protocols 2019, 14: 1280-1292. PMID: 30894693, DOI: 10.1038/s41596-019-0142-x.Peer-Reviewed Original ResearchBladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis
Yeh J, Lu M, Alvarez-Lugo L, Chai TC. Bladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis. American Journal Of Physiology. Renal Physiology 2019, 316: f617-f623. PMID: 30648906, DOI: 10.1152/ajprenal.00554.2018.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsUrinary tract infectionInnate immune responseImmune responseBK channel activityUrinary tract infection pathogenesisChannel activityFemale C57BL/6 miceInflammatory protein-2Voltage-gated potassium channelsUropathogenic Escherichia coliInhibitor iberiotoxinUPEC exposureUTI pathogenesisInflammatory biomarkersTract infectionsC57BL/6 miceIL-6Urinary biomarkersUrinary changesBiomarker levelsInfection pathogenesisUrine specimensProtein 10LPS inoculationSame biomarkers
2018
Mouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure
Acevedo‐Alvarez M, Yeh J, Alvarez‐Lugo L, Lu M, Sukumar N, Hill WG, Chai TC. Mouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure. Neurourology And Urodynamics 2018, 37: 2398-2405. PMID: 29682797, DOI: 10.1002/nau.23592.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsUrinary tract infectionOveractive bladderOVX miceVoiding behaviorFemale C57BL6/J miceC57BL6/J micePost-menopausal womenEffects of ovariectomyBehavior changeMicturition changesTransurethral instillationLPS instillationTract infectionsSham surgeryLPS exposureJ miceCOX-2OVX surgeryDay 1Day 3Consecutive daysSurgeryMiceSpot assayGene expression changesLipopolysaccharide stimulates BK channel activity in bladder umbrella cells
Lu M, Li JR, Alvarez-Lugo L, Li Y, Yu S, Li X, Shi B, Chai TC. Lipopolysaccharide stimulates BK channel activity in bladder umbrella cells. American Journal Of Physiology - Cell Physiology 2018, 314: c643-c653. PMID: 29466671, DOI: 10.1152/ajpcell.00339.2017.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCyclic AMP-Dependent Protein KinasesFemaleLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLipopolysaccharide ReceptorsLipopolysaccharidesLymphocyte Antigen 96Membrane PotentialsMice, Inbred C57BLPatch-Clamp TechniquesPotassiumSignal TransductionToll-Like Receptor 4Urinary BladderUrinary Tract InfectionsUrotheliumConceptsBK channel activityBK channelsChannel activityUmbrella cellsUrinary tract infectionFemale C57BL6 micePotassium channel inhibitorsUropathogenic Escherichia coliProtein kinase ATract infectionsLPS effectsC57BL6 miceBladder urotheliumLamina propriaMin of exposureChannel inhibitorsBacterial infectionsLPS receptorUrothelial tissuesUrothelial cellsUrotheliumLipopolysaccharidePotassium channelsRT-PCRPKA blocker
2017
MP82-07 UROTHELIAL GENES MODULATING MICTURITION BEHAVIOR INDUCED BY A REPETITIVE LIPOPOLYSACCHARIDE (LPS) EXPOSURE IN AN OVARIECTOMIZED (OVX) MOUSE MODEL
Acevedo-Alvarez M, Yeh J, Alvarez-Lugo L, Lu M, Sukumar N, Hill W, Chai T. MP82-07 UROTHELIAL GENES MODULATING MICTURITION BEHAVIOR INDUCED BY A REPETITIVE LIPOPOLYSACCHARIDE (LPS) EXPOSURE IN AN OVARIECTOMIZED (OVX) MOUSE MODEL. Journal Of Urology 2017, 197: e1099. DOI: 10.1016/j.juro.2017.02.2554.Peer-Reviewed Original ResearchPD12-05 BIG POTASSIUM CHANNEL (BK) ACTIVITY IN FEMALE MOUSE BLADDER UMBRELLA CELLS IS ENHANCED BY BACTERIAL LIPOPOLYSACCHARIDE: AN ACUTE HOST RESPONSE IN URINARY TRACT INFECTION (UTI) PATHOGENESIS
Lu M, Li J, Li Y, Yu S, Chai T. PD12-05 BIG POTASSIUM CHANNEL (BK) ACTIVITY IN FEMALE MOUSE BLADDER UMBRELLA CELLS IS ENHANCED BY BACTERIAL LIPOPOLYSACCHARIDE: AN ACUTE HOST RESPONSE IN URINARY TRACT INFECTION (UTI) PATHOGENESIS. Journal Of Urology 2017, 197: e267. DOI: 10.1016/j.juro.2017.02.680.Peer-Reviewed Original Research
2016
Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS)
Li Y, Lu M, Alvarez‐Lugo L, Chen G, Chai TC. Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS). Neurourology And Urodynamics 2016, 36: 1020-1025. PMID: 27337494, DOI: 10.1002/nau.23057.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBladder urotheliumCyclooxygenase-2GM-CSFCyclooxygenase-1GM-CSFRαBladder tissueMRNA expressionTumor necrosis factor αCOX-2 mRNA expressionVivo LPS exposureVascular endothelial growth factorNecrosis factor αDose-dependent releaseIncrease of VEGFGranulocyte-macrophage colony-stimulating factor (GM-CSF) signalingBladder urothelial cellsConcentrations of lipopolysaccharideGM-CSF mRNA expressionEndothelial growth factorGM-CSF antibodyMouse bladder urotheliumGM-CSF activityLPS exposurePain transductionSingle doseRomk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion*
Dong K, Yan Q, Lu M, Wan L, Hu H, Guo J, Boulpaep E, Wang W, Giebisch G, Hebert SC, Wang T. Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion*. Journal Of Biological Chemistry 2016, 291: 5259-5269. PMID: 26728465, PMCID: PMC4777858, DOI: 10.1074/jbc.m115.707877.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2015
Mucosal signaling in the bladder
Chai TC, Russo A, Yu S, Lu M. Mucosal signaling in the bladder. Autonomic Neuroscience 2015, 200: 49-56. PMID: 26422993, DOI: 10.1016/j.autneu.2015.08.009.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsElectrical field stimulationLamina propriaNerve fibersMuscularis mucosaeNeural activitySpontaneous electrical activityNon-neuronal cellsSmooth muscle fibersMucosal contractionEfferent nervesBladder disordersAutonomic nervesAfferent activityBladder mucosaField stimulationHigh prevalenceMucosaStretch stimulusUrothelial cellsNerveElectrical activityMuscle fibersLuminal sideUrotheliumMultilayered urothelium
2012
SeSAME/EAST syndrome—phenotypic variability and delayed activity of the distal convoluted tubule
Scholl UI, Dave HB, Lu M, Farhi A, Nelson-Williams C, Listman JA, Lifton RP. SeSAME/EAST syndrome—phenotypic variability and delayed activity of the distal convoluted tubule. Pediatric Nephrology 2012, 27: 2081-2090. PMID: 22907601, DOI: 10.1007/s00467-012-2219-4.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAbsorptionAge FactorsBiomarkersChildDNA Mutational AnalysisElectrolytesFemaleGenetic Predisposition to DiseaseHearing Loss, SensorineuralHEK293 CellsHomozygoteHumansInfantIntellectual DisabilityKidney Tubules, DistalMaleMembrane PotentialsMicroscopy, ConfocalMutationPedigreePhenotypePotassium Channels, Inwardly RectifyingPredictive Value of TestsSeizuresTransfectionConceptsGitelman syndromeAutosomal recessive syndromeRenal featuresElectrolyte disordersHypokalemic alkalosisClinical presentationElectrolyte imbalanceMedical recordsSignificant worseningBiochemical lossSensorineural deafnessSalt reabsorptionConclusionsThese findingsRecessive syndromeSimilar findingsSyndromeAge 5Mental retardationUnreported familiesSeizuresChannel functionAgeAffected membersFirst yearTubules
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