2013
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex. Neuron 2013, 77: 736-749. PMID: 23439125, PMCID: PMC3584418, DOI: 10.1016/j.neuron.2012.12.032.Peer-Reviewed Original ResearchConceptsPersistent firingDorsolateral prefrontal cortexAMPA receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexSystemic ketamine administrationPersistent neuronal firingAMPAR blockadePrimate dlPFCKetamine actionKetamine administrationNMDAR blockadeNMDA receptorsSystemic ketamineNetwork firingNeuronal firingAlzheimer's diseaseReceptor influencesImpair cognitionResponse cellsRecurrent excitationSensory stimulation
2010
Dynamic Network Connectivity: A new form of neuroplasticity
Arnsten AF, Paspalas CD, Gamo NJ, Yang Y, Wang M. Dynamic Network Connectivity: A new form of neuroplasticity. Trends In Cognitive Sciences 2010, 14: 365-375. PMID: 20554470, PMCID: PMC2914830, DOI: 10.1016/j.tics.2010.05.003.Peer-Reviewed Original Research
2007
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 2007, 10: 376-384. PMID: 17277774, DOI: 10.1038/nn1846.Peer-Reviewed Original ResearchAction PotentialsAnalysis of VarianceAnimalsBehavior, AnimalCyclic AMPDopamine AgentsDose-Response Relationship, DrugDrug InteractionsIontophoresisMacaca mulattaMaleMaze LearningMemory, Short-TermNeuronsNeuropsychological TestsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, Dopamine D1Sensitivity and SpecificityThionucleotides
2004
Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory
Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein Kinase C Overactivity Impairs Prefrontal Cortical Regulation of Working Memory. Science 2004, 306: 882-884. PMID: 15514161, DOI: 10.1126/science.1100021.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-AgonistsAlkaloidsAnimalsBenzophenanthridinesCarbolinesElectrophysiologyEnzyme ActivationFemaleImidazolesLithium CarbonateMacaca mulattaMaleMemoryNeuronsPhenanthridinesPrefrontal CortexProtein Kinase CRatsRats, Sprague-DawleyReceptors, Adrenergic, alpha-1Signal TransductionStress, PhysiologicalTetradecanoylphorbol AcetateValproic AcidConceptsPrefrontal cortical regulationPrefrontal cortexPrefrontal cortical cognitive functionCortical regulationCortical cognitive functionsPrefrontal cortical dysfunctionWorking memoryElectrophysiological measuresCognitive functionRepresentational knowledgeThought disorderImpaired judgmentBrain regionsStress exposureMemoryCortical dysfunctionHigher brain regionsCortexThoughtDistractibilityEmotionsImpulsivityHigh levelsJudgmentsBehavior