2013
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex. Neuron 2013, 77: 736-749. PMID: 23439125, PMCID: PMC3584418, DOI: 10.1016/j.neuron.2012.12.032.Peer-Reviewed Original ResearchConceptsPersistent firingDorsolateral prefrontal cortexAMPA receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexSystemic ketamine administrationPersistent neuronal firingAMPAR blockadePrimate dlPFCKetamine actionKetamine administrationNMDAR blockadeNMDA receptorsSystemic ketamineNetwork firingNeuronal firingAlzheimer's diseaseReceptor influencesImpair cognitionResponse cellsRecurrent excitationSensory stimulation
2012
Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia
Paspalas CD, Wang M, Arnsten AF. Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia. Cerebral Cortex 2012, 23: 1643-1654. PMID: 22693343, PMCID: PMC3673177, DOI: 10.1093/cercor/bhs152.Peer-Reviewed Original ResearchAnimalsCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 4Dendritic SpinesHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsImmunohistochemistryMacaca mulattaMemory DisordersMemory, Short-TermMicroscopy, ImmunoelectronPatch-Clamp TechniquesPrefrontal CortexReceptors, Dopamine D1Schizophrenia
2010
Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors
Gamo NJ, Wang M, Arnsten AF. Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1011-1023. PMID: 20855046, PMCID: PMC2999884, DOI: 10.1016/j.jaac.2010.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAnimalsAppetitive BehaviorAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityBrain MappingCentral Nervous System StimulantsChildDisease Models, AnimalDose-Response Relationship, DrugFemaleHumansMacaca mulattaMaleMemory, Short-TermMethylphenidateNerve NetOrientationPrefrontal CortexPropylaminesPyramidal CellsReceptors, Adrenergic, alpha-2Receptors, Dopamine D1SaccadesConceptsAttention-deficit/hyperactivity disorder treatmentOptimal dosesPFC cognitive functionDopamine receptor antagonistDopamine D1 receptorsAttention-deficit/hyperactivity disorderAdrenoceptor antagonistPrefrontal cortex functionΑ2-adrenergicCellular levelReceptor antagonistD1 receptorsDopamine receptorsTherapeutic effectReceptor mechanismsSCH23390Moderate dosesAtomoxetineIndirect stimulationDisorder treatmentHigh dosesCortex functionPersistent firingCognitive functionReceptor action
2007
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neuroscience 2007, 10: 376-384. PMID: 17277774, DOI: 10.1038/nn1846.Peer-Reviewed Original ResearchAction PotentialsAnalysis of VarianceAnimalsBehavior, AnimalCyclic AMPDopamine AgentsDose-Response Relationship, DrugDrug InteractionsIontophoresisMacaca mulattaMaleMaze LearningMemory, Short-TermNeuronsNeuropsychological TestsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, Dopamine D1Sensitivity and SpecificityThionucleotides