2016
Serum mass profile signature as a biomarker of early lung cancer
Widlak P, Pietrowska M, Polanska J, Marczyk M, Ros-Mazurczyk M, Dziadziuszko R, Jassem J, Rzyman W. Serum mass profile signature as a biomarker of early lung cancer. Lung Cancer 2016, 99: 46-52. PMID: 27565913, DOI: 10.1016/j.lungcan.2016.06.011.Peer-Reviewed Original ResearchConceptsEarly lung cancerLung cancerNegative predictive valuePredictive valueComputed tomographyEarly-stage lung cancerLow-dose computed tomographyIndeterminate pulmonary nodulesStage lung cancerPotential clinical usefulnessPositive predictive valueValidation cohortHealthy controlsClinical usefulnessDiscovery cohortBlood samplesIndependent cohortWeight serum fractionsPulmonary nodulesIndependent sample setCancerPatientsHealthy participantsMolecular biomarkersCohort
2015
Signal Partitioning Algorithm for Highly Efficient Gaussian Mixture Modeling in Mass Spectrometry
Polanski A, Marczyk M, Pietrowska M, Widlak P, Polanska J. Signal Partitioning Algorithm for Highly Efficient Gaussian Mixture Modeling in Mass Spectrometry. PLOS ONE 2015, 10: e0134256. PMID: 26230717, PMCID: PMC4521892, DOI: 10.1371/journal.pone.0134256.Peer-Reviewed Original ResearchConceptsGaussian mixture modelingMixture modelGaussian mixture modelPeak detectionProteomic mass spectraFeature extractionPartitioning algorithmEfficient algorithmSignal compressionSoftware packageAlgorithmMain ideaMixture modelingModeling approachModelingDatasetApplicationsDetectionPreliminary resultsDetection efficiencyProteomic datasetsMixture modeling approachModelDifferent typesHigh resolution