2022
Comprehensive Analysis of Metabolic Isozyme Targets in Cancer
Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O'Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L. Comprehensive Analysis of Metabolic Isozyme Targets in Cancer. Cancer Research 2022, 82: 1698-1711. PMID: 35247885, PMCID: PMC10883296, DOI: 10.1158/0008-5472.can-21-3983.Peer-Reviewed Original ResearchConceptsPotential therapeutic targetAcetyl-CoA carboxylase 1Therapeutic targetCancer typesCell linesBreast cancer viabilityPatient-derived xenograftsNovel metabolic targetsCorresponding cell linesExpression patternsDrug treatmentMatching normal tissuesRelated commentaryTumor growthMalignant transformationSmall molecule inhibitionCancer viabilityCancer Cell Line EncyclopediaNormal tissuesMetabolic vulnerabilitiesCarboxylase 1Anticancer therapyCellular changesCell proliferationMetabolic reprogramming
2020
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
Drobin K, Marczyk M, Halle M, Danielsson D, Papiez A, Sangsuwan T, Bendes A, Hong MG, Qundos U, Harms-Ringdahl M, Wersäll P, Polanska J, Schwenk JM, Haghdoost S. Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer. Cancers 2020, 12: 753. PMID: 32235817, PMCID: PMC7140105, DOI: 10.3390/cancers12030753.Peer-Reviewed Original ResearchSingle nucleotide polymorphismsCancer patientsRadiosensitive patientsProteomic dataDNA repairSNP variantsRadiation-induced toxicityNeck cancer patientsLong-term survivalPredictors of radiosensitivityNucleotide polymorphismsProteinAdverse health effectsPlasma proteomicsGrowth capacityNeck cancerPredictive proteinsBreast cancerImmune responsePatient radiosensitivityPatientsStudy setDNA genotypingMolecular profilingNormal tissues
2014
Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients
Jelonek K, Pietrowska M, Ros M, Zagdanski A, Suchwalko A, Polanska J, Marczyk M, Rutkowski T, Skladowski K, Clench MR, Widlak P. Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients. International Journal Of Molecular Sciences 2014, 15: 6609-6624. PMID: 24747595, PMCID: PMC4013650, DOI: 10.3390/ijms15046609.Peer-Reviewed Original ResearchConceptsSerum lipidomeConformal radiotherapyMedium dosesEnd of radiotherapyNeck cancer patientsRadiation-induced changesWhole patient bodyBody responsePost-treatment samplesDoses of radiationBlood levelsCancer patientsNeck cancerBlood samplesRadiotherapyNormal tissuesPatientsDosesCancer radiotherapyLipidomePatient's bodyTreatment samplesTissueLipid extractsCancer