2021
A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila
Sareen PF, McCurdy LY, Nitabach MN. A neuronal ensemble encoding adaptive choice during sensory conflict in Drosophila. Nature Communications 2021, 12: 4131. PMID: 34226544, PMCID: PMC8257655, DOI: 10.1038/s41467-021-24423-y.Peer-Reviewed Original ResearchFood odors decrease longevity via a brain–gut axis
Price K, Nitabach M. Food odors decrease longevity via a brain–gut axis. Nature Aging 2021, 1: 237-238. PMID: 37118407, DOI: 10.1038/s43587-021-00047-1.Peer-Reviewed Original Research
2013
Genetically Targeted Optical Electrophysiology in Intact Neural Circuits
Cao G, Platisa J, Pieribone VA, Raccuglia D, Kunst M, Nitabach MN. Genetically Targeted Optical Electrophysiology in Intact Neural Circuits. Cell 2013, 154: 904-913. PMID: 23932121, PMCID: PMC3874294, DOI: 10.1016/j.cell.2013.07.027.Peer-Reviewed Original ResearchConceptsIntact neural circuitsNeural circuitsIntact brain tissueMembrane potentialNeuronal information processingNervous systemAction potentialsBrain tissueNeuronsStudy of intracellularElectrical activityKey cellular parametersMultiple neuronsElectrical eventsSubthreshold eventsNeurite branchesOptical electrophysiologyReliable recordingCellular parametersVoltage indicatorsFluorescent voltage indicatorsBrain
2012
Deep sequencing the circadian and diurnal transcriptome of Drosophila brain
Hughes ME, Grant GR, Paquin C, Qian J, Nitabach MN. Deep sequencing the circadian and diurnal transcriptome of Drosophila brain. Genome Research 2012, 22: 1266-1281. PMID: 22472103, PMCID: PMC3396368, DOI: 10.1101/gr.128876.111.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingAnimalsBase SequenceBrainCircadian ClocksCircadian RhythmDrosophila melanogasterExonsGene Expression ProfilingMolecular Sequence AnnotationPhotoperiodRNA EditingRNA IsoformsRNA Splice SitesRNA, UntranslatedSequence AlignmentSequence Analysis, RNATranscription, GeneticTranscriptomeConceptsKey circadian genesRNA editingNoncoding RNAsCircadian genesDrosophila brainGenome-wide mapsEukaryotic circadian clocksCircadian transcriptional rhythmsSnoRNA host genesTranslational feedback loopsSmall nucleolar RNAsNovel splicing eventsAlternative splice isoformsDark diurnal cyclesFrequency of RNAPrevious microarray studyDiurnal transcriptomeDrosophila melanogaster brainTranscriptional rhythmsCircadian transcriptomeNcRNA expressionRibosomal biogenesisModENCODE consortiumSplicing eventsAlternative splicing
2011
Synchronized Bilateral Synaptic Inputs to Drosophila melanogaster Neuropeptidergic Rest/Arousal Neurons
McCarthy EV, Wu Y, deCarvalho T, Brandt C, Cao G, Nitabach MN. Synchronized Bilateral Synaptic Inputs to Drosophila melanogaster Neuropeptidergic Rest/Arousal Neurons. Journal Of Neuroscience 2011, 31: 8181-8193. PMID: 21632940, PMCID: PMC3125135, DOI: 10.1523/jneurosci.2017-10.2011.Peer-Reviewed Original ResearchConceptsSynaptic inputsWhole-cell patch-clamp recordingsNicotinic acetylcholine receptor antagonistDual whole-cell patch-clamp recordingsAcetylcholine receptor antagonistNicotinic ACh receptorsSynchronous synaptic inputPatch-clamp recordingsWake-promoting neuronsLarge ventrolateral neuronsArousal neuronsSodium blockersGABAergic inputsCholinergic inputReceptor antagonistSynaptic circuitryACh receptorsNeurotransmitter receptorsBilateral inputSynaptic connectionsΑ-bungarotoxinVentrolateral neuronsContralateral pairsFiring patternsNeurons