2022
A molecular clock controls periodically driven cell migration in confined spaces
Lee SH, Hou JC, Hamidzadeh A, Yousafzai MS, Ajeti V, Chang H, Odde DJ, Murrell M, Levchenko A. A molecular clock controls periodically driven cell migration in confined spaces. Cell Systems 2022, 13: 514-529.e10. PMID: 35679858, DOI: 10.1016/j.cels.2022.05.005.Peer-Reviewed Original ResearchConceptsCell migrationSmall GTPase RhoAFaster cell migrationNegative feedback loopExchange factorMolecular clockGEF-H1RhoA guanineGTPase RhoAMicrotubule dynamicsMolecular mechanismsClock controlCell spreadExtracellular matrixIntracellular CaTissue reorganizationFeedback loopMigrationRhoAAbundanceGuanineBetter understanding
2015
High‐content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics
Harkness T, McNulty J, Prestil R, Seymour S, Klann T, Murrell M, Ashton R, Saha K. High‐content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics. Biotechnology Journal 2015, 10: 1555-1567. PMID: 26097126, PMCID: PMC6948850, DOI: 10.1002/biot.201400756.Peer-Reviewed Original ResearchConceptsChromatin dynamicsHigh-content imagingMicroenvironmental cuesHuman cellsCellular microenvironment influencesHuman cell biologySingle cell geometryCell-cell contactExtracellular matrix connectionsActin cytoskeletonHuman cell behaviorCytoskeletal organizationHigh-content screening technologyCell biologyBiophysical cuesCellular responsesCellular microenvironmentNuclear elongationCell behaviorCellular biophysicsSubcellular imagingComplex milieuCellular geometryHuman fibroblastsCytoskeleton