A molecular clock controls periodically driven cell migration in confined spaces
Lee SH, Hou JC, Hamidzadeh A, Yousafzai MS, Ajeti V, Chang H, Odde DJ, Murrell M, Levchenko A. A molecular clock controls periodically driven cell migration in confined spaces. Cell Systems 2022, 13: 514-529.e10. PMID: 35679858, DOI: 10.1016/j.cels.2022.05.005.Peer-Reviewed Original ResearchConceptsCell migrationSmall GTPase RhoAFaster cell migrationNegative feedback loopExchange factorMolecular clockGEF-H1RhoA guanineGTPase RhoAMicrotubule dynamicsMolecular mechanismsClock controlCell spreadExtracellular matrixIntracellular CaTissue reorganizationFeedback loopMigrationRhoAAbundanceGuanineBetter understanding