2024
Substrate geometry and topography induce F-actin reorganization and chiral alignment in an adherent model cortex
Sakamoto R, Murrell M. Substrate geometry and topography induce F-actin reorganization and chiral alignment in an adherent model cortex. Cell Reports Physical Science 2024, 5: 102338. DOI: 10.1016/j.xcrp.2024.102338.Peer-Reviewed Original ResearchF-actin organizationF-actin networkF-actinF-actin reorganizationSubstrate featuresActin cortexCytoskeletal organizationGiant unilamellar vesiclesIntracellular signalingCell adhesionGeometry sensingLiposome shapeCell membraneMembrane deformationUnilamellar vesiclesAdherent liposomeCellsActinOrganizationVesiclesAdhesionLiposomes
2015
High‐content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics
Harkness T, McNulty J, Prestil R, Seymour S, Klann T, Murrell M, Ashton R, Saha K. High‐content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics. Biotechnology Journal 2015, 10: 1555-1567. PMID: 26097126, PMCID: PMC6948850, DOI: 10.1002/biot.201400756.Peer-Reviewed Original ResearchConceptsChromatin dynamicsHigh-content imagingMicroenvironmental cuesHuman cellsCellular microenvironment influencesHuman cell biologySingle cell geometryCell-cell contactExtracellular matrix connectionsActin cytoskeletonHuman cell behaviorCytoskeletal organizationHigh-content screening technologyCell biologyBiophysical cuesCellular responsesCellular microenvironmentNuclear elongationCell behaviorCellular biophysicsSubcellular imagingComplex milieuCellular geometryHuman fibroblastsCytoskeleton