2019
Holding open the door reveals a new view of polycystin channel function
Caplan MJ. Holding open the door reveals a new view of polycystin channel function. EMBO Reports 2019, 20: embr201949156. PMID: 31556469, PMCID: PMC6832007, DOI: 10.15252/embr.201949156.Peer-Reviewed Original Research
2003
TRANSPORT PROTEIN TRAFFICKING IN POLARIZED CELLS
Muth TR, Caplan MJ. TRANSPORT PROTEIN TRAFFICKING IN POLARIZED CELLS. Annual Review Of Cell And Developmental Biology 2003, 19: 333-366. PMID: 14570573, DOI: 10.1146/annurev.cellbio.19.110701.161425.Peer-Reviewed Original ResearchConceptsTransport proteinsMembrane trafficking processesIon transport proteinsIon transport activityProtein traffickingCellular machineryTrafficking processesPolarized cellsPlasma membraneEndocytic retrievalSubcellular distributionPhysiological functionsTransport activityCell surfaceBiochemical natureCell membraneIntracellular populationProteinMembraneTraffickingMachineryRegulationCellsDomain
1998
Identification of Sorting Determinants in the C-terminal Cytoplasmic Tails of the γ-Aminobutyric Acid Transporters GAT-2 and GAT-3*
Muth T, Ahn J, Caplan M. Identification of Sorting Determinants in the C-terminal Cytoplasmic Tails of the γ-Aminobutyric Acid Transporters GAT-2 and GAT-3*. Journal Of Biological Chemistry 1998, 273: 25616-25627. PMID: 9748227, DOI: 10.1074/jbc.273.40.25616.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological TransportCarrier ProteinsCells, CulturedCloning, MolecularDogsFluorescent Antibody TechniqueGABA Plasma Membrane Transport ProteinsGamma-Aminobutyric AcidGenes, mycIon ChannelsKidneyMembrane ProteinsMembrane Transport ProteinsMicroscopy, ConfocalMolecular Sequence DataRecombinant Fusion ProteinsSequence DeletionConceptsC-terminal cytoplasmic tailIon transport proteinsMadin-Darby canine kidney cellsCytoplasmic tailMembrane proteinsC-terminusCanine kidney cellsTransporter familyAmino acidsBasolateral distributionTransport proteinsGAT-2Polytopic membrane proteinsProtein-based signalsProtein-protein interactionsTerminal cytoplasmic tailC-terminal sequencesKidney cellsClass of polypeptidesEpithelial cellsApical sortingPDZ domainChimeric transportersPolarized sortingSorting determinant
1997
Membrane polarity in epithelial cells: protein sorting and establishment of polarized domains
Caplan MJ. Membrane polarity in epithelial cells: protein sorting and establishment of polarized domains. American Journal Of Physiology 1997, 272: f425-f429. PMID: 9140041, DOI: 10.1152/ajprenal.1997.272.4.f425.Peer-Reviewed Original ResearchConceptsTransport proteinsEpithelial cellsDistinct surface domainsEpithelial cell typesProtein sortingBiological specializationCellular pathwaysPlasma membranePolarized epitheliumElegant networkMembrane polarityCell typesBasolateral surfaceDistinct populationsProteinBasolateral portionPhysiological propertiesSurface domainsCellsAbsolute prerequisiteDomainPlasmalemmaPathwaySortingMembrane
1996
Real-time detection of the surface delivery of newly synthesized membrane proteins.
Andreose JS, Fumagalli G, Sigworth FJ, Caplan MJ. Real-time detection of the surface delivery of newly synthesized membrane proteins. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 7661-7666. PMID: 8755532, PMCID: PMC38803, DOI: 10.1073/pnas.93.15.7661.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBungarotoxinsCell LineCell MembraneElectrophysiologyFourier AnalysisGolgi ApparatusGuanosine 5'-O-(3-Thiotriphosphate)Guanosine TriphosphateIon ChannelsKineticsMembrane PotentialsMembrane ProteinsMiceMuscle, SkeletalProtein Processing, Post-TranslationalReceptors, NicotinicTime FactorsConceptsMembrane proteinsPlasma membraneCell surfaceDegrees C temperature blockCultured muscle cellsConstitutive trafficTransport vesiclesConstitutive deliveryFusion eventsSurface deliveryFusion poreExocytotic vesiclesAChR moleculeGolgi complexTemperature blockAChR proteinNicotinic acetylcholine receptorsIon channel propertiesMost cellsVesiclesProteinCurrent fluctuationsMuscle cellsAcetylcholine receptorsGuanosine 5'
1987
Monoclonal antibody localization of Na+-K+-ATPase in the exocrine pancreas and parotid of the dog
Smith ZD, Caplan MJ, Forbush B, Jamieson JD. Monoclonal antibody localization of Na+-K+-ATPase in the exocrine pancreas and parotid of the dog. American Journal Of Physiology 1987, 253: g99-g109. PMID: 2441610, DOI: 10.1152/ajpgi.1987.253.2.g99.Peer-Reviewed Original ResearchConceptsDuct cellsAcinar cellsRenal tubular cellsInterlobular duct cellsSodium pumpMonoclonal antibody localizationDuct-derived cellsIntralobular duct cellsTubular cellsElectrolyte secretionFrozen sectionsPancreasExocrine pancreasMonoclonal antibodiesOligosaccharide determinantsParotidAntibody localizationParotid cellsAntibodiesDog pancreasThin frozen sections
1986
Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast
Baron R, Neff L, Roy C, Boisvert A, Caplan M. Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell 1986, 46: 311-320. PMID: 2424614, DOI: 10.1016/0092-8674(86)90748-8.Peer-Reviewed Original ResearchConceptsPlasma membraneOsteoclast plasma membraneBone resorptionBeta subunitProton translocationMonoclonal antibodiesImmunoblot analysisBone marrow cellsKidney tubule cellsExtracellular compartmentBone marrow preparationsMembraneMarrow cellsBone cellsTubule cellsCellsProton transportOsteoclast membraneMarrow preparationsIon transportOsteoclastsSodium pumpSpecific markersResorptionAntibodies