Antimicrobial activity of antisense peptide–peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms
Otsuka T, Brauer AL, Kirkham C, Sully EK, Pettigrew MM, Kong Y, Geller BL, Murphy TF. Antimicrobial activity of antisense peptide–peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms. Journal Of Antimicrobial Chemotherapy 2016, 72: 137-144. PMID: 27986898, PMCID: PMC5161047, DOI: 10.1093/jac/dkw384.Peer-Reviewed Original ResearchEffect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease
Pettigrew MM, Tsuji BT, Gent JF, Kong Y, Holden PN, Sethi S, Murphy TF. Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrobial Agents And Chemotherapy 2016, 60: 4151-4158. PMID: 27139476, PMCID: PMC4914697, DOI: 10.1128/aac.00301-16.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsCiprofloxacinFluoroquinolonesHaemophilus influenzaeLevofloxacinMacrolidesMicrobial Sensitivity TestsMoxifloxacinPulmonary Disease, Chronic ObstructiveConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseH. influenzae isolatesH. influenzaePulmonary diseaseFluoroquinolone administrationInfluenzae isolatesDevelopment of resistanceHaemophilus influenzaeEradication of carriageEffects of macrolidesQuinolone resistance-determining regionsMICs of antibioticsEffects of fluoroquinolonesResistance-determining regionMacrolide administrationCOPD patientsEffects of antibioticsAzithromycin MICsAntibiotic useSusceptibility breakpointsAntibiotic susceptibilityMacrolide susceptibilityInfluenzaeAdministrationThe human microbiota: novel targets for hospital-acquired infections and antibiotic resistance
Pettigrew MM, Johnson JK, Harris AD. The human microbiota: novel targets for hospital-acquired infections and antibiotic resistance. Annals Of Epidemiology 2016, 26: 342-347. PMID: 26994507, PMCID: PMC4892961, DOI: 10.1016/j.annepidem.2016.02.007.Peer-Reviewed Original ResearchConceptsMultidrug-resistant organismsSpread of MDROsInfection control interventionsHealth care settingsCare settingsColonization resistanceControl interventionsTraditional infection control measuresInfection control measuresAntibiotic resistanceControl of MDROsHospital-acquired infectionsHealth care professionalsHospitalized patientsIntact microbiotaAntibiotic useMDRO transmissionEpidemiologic studiesInfection controlAntimicrobial stewardshipCare professionalsHealthy microbiotaExpansion of pathogensResistant organismsNovel target