2020
Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota
Brugger SD, Eslami SM, Pettigrew MM, Escapa IF, Henke MT, Kong Y, Lemon KP. Dolosigranulum pigrum Cooperation and Competition in Human Nasal Microbiota. MSphere 2020, 5: 10.1128/msphere.00852-20. PMID: 32907957, PMCID: PMC7485692, DOI: 10.1128/msphere.00852-20.Peer-Reviewed Original ResearchConceptsMicrobe-microbe interactionsHuman nasal microbiotaGenomic analysisPhenotypic interactionsBiosynthetic gene clusterSmall genomesNasal microbiotaGene clusterAccessory genomeKey nutrientsNew insightsGenomic capacityBacterial residentsPathogenic speciesNasal microbiota compositionBeneficial bacteriumFunctional assaysDiverse repertoireHuman hostGenomeSpeciesAcid productionMicrobiotaNasal bacteriaBacteria
2012
Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media
Ruohola A, Pettigrew MM, Lindholm L, Jalava J, Räisänen KS, Vainionpää R, Waris M, Tähtinen PA, Laine MK, Lahti E, Ruuskanen O, Huovinen P. Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media. Journal Of Infection 2012, 66: 247-254. PMID: 23266462, PMCID: PMC3571106, DOI: 10.1016/j.jinf.2012.12.002.Peer-Reviewed Original ResearchConceptsRisk of AOMAcute otitis mediaMiddle ear effusionAOM groupRespiratory virusesAOM pathogensAcute symptomsOtitis mediaEar effusionM. catarrhalisAcute inflammatory signsNasopharyngeal bacterial colonizationRespiratory tract infectionsOtoscopic signsTract infectionsInflammatory signsNasopharyngeal samplesSymptomatic childrenNasopharyngeal bacteriaH. influenzaePneumatic otoscopyS. pneumoniaeViral interactionsBacterial colonizationEffusion
2011
Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection
Pettigrew MM, Gent JF, Pyles RB, Miller AL, Nokso-Koivisto J, Chonmaitree T. Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection. Journal Of Clinical Microbiology 2011, 49: 3750-3755. PMID: 21900518, PMCID: PMC3209086, DOI: 10.1128/jcm.01186-11.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCohort StudiesComorbidityHaemophilus influenzaeHuman bocavirusHumansInfantMetapneumovirusMicrobial InteractionsMoraxella catarrhalisOtitis MediaPolymerase Chain ReactionProspective StudiesRespiratory Syncytial VirusesRespiratory Tract InfectionsRisk AssessmentStreptococcus pneumoniaeConceptsUpper respiratory tract infectionAcute otitis mediaRespiratory tract infectionsRespiratory syncytial virusOtitis mediaOtitis media riskTract infectionsViral loadSyncytial virusHaemophilus influenzaeStreptococcus pneumoniaeRespiratory Syncytial Virus LoadMedium-risk factorsRepeated-measures logistic regressionRSV viral loadViral-bacterial interactionsHigh viral loadSpecific virusesBacterial pathogensChildren ages 6Common complicationRespiratory virusesMedium riskProspective studyHuman bocavirus