2006
Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing.
Banno K, Okamura K, Kryger MH. Adaptive servo-ventilation in patients with idiopathic Cheyne-Stokes breathing. Journal Of Clinical Sleep Medicine 2006, 2: 181-6. PMID: 17557493, DOI: 10.5664/jcsm.26514.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureCheyne-Stokes breathingHours of sleepHeart failureBreathing patternCentral sleep apneaPositive airway pressurePeriodic breathing patternAbnormal breathing patternsSerious medical problemSubjective daytime alertnessAbnormal breathing eventsAirway pressureRenal failureMedical illnessSleep apneaStokes breathingDaytime alertnessEffective treatmentPatientsSleep respirationBreathing eventsMedical problemsDaytime performanceBreathing
2002
Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers
Kryger MH, Otake K, Foerster J. Low body stores of iron and restless legs syndrome: a correctable cause of insomnia in adolescents and teenagers. Sleep Medicine 2002, 3: 127-132. PMID: 14592231, DOI: 10.1016/s1389-9457(01)00160-5.Peer-Reviewed Original ResearchRestless legs syndromePercent iron saturationIron storesSubjective sleep latencyFerritin levelsLegs syndromeSleep latencySymptoms of RLSBody storesLow serum ferritin levelsTotal iron binding capacitySerum ferritin levelsSevere sleep onset insomniaLow body storesIron binding capacityHours of sleepSleep onset insomniaOral ironCorrectable causeExcessive daytimeSerum ferritinChronic insomniaSerum ironIron statusOnset insomnia
1998
Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients
Pieta J, Miliar T, Zacharias J, Fine A, Kryger M. Effect of Pergolide on Restless Legs and Leg Movements in Sleep in Uremic Patients. Sleep 1998, 21: 617-622. PMID: 9779521, DOI: 10.1093/sleep/21.6.617.Peer-Reviewed Original ResearchConceptsRestless legs syndromeLeg movementsRestless legsUremic patientsSubjective improvementTreatment of RLSDouble-blind placebo-controlled crossover studyPlacebo-controlled crossover studyRestless legs symptomsEffects of pergolideContinuous peritoneal dialysisPeriodic limb movementsSmall patient groupsHours of sleepQuality of sleepFirst hourChronic hemodialysisLeg symptomsCrossover studyLegs syndromePeritoneal dialysisIncremental dosesPatient groupSleep architectureSleep disruption
1996
L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia
Walker S, Fine A, Kryger M. L-DOPA/Carbidopa for Nocturnal Movement Disorders in Uremia. Sleep 1996, 19: 214-218. PMID: 8723378, DOI: 10.1093/sleep/19.3.214.Peer-Reviewed Original ResearchConceptsL-dopa/carbidopaRestless legs syndromeSlow-wave sleepLeg movementsSleep timeTreatment of RLSMovement arousal indexNocturnal movement disordersSingle bedtime doseChronic hemodialysis patientsPeriodic limb movementsHours of sleepBedtime doseActive medicationHemodialysis patientsCrossover studyLegs syndromeUremic patientsArousal indexMovement disordersSleep disruptionFrequent dosingObjective improvementSleep disordersEffective treatment
1993
Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration
Biberdorf D, Steens R, Millar T, Kryger M. Benzodiazepines in Congestive Heart Failure: Effects of Temazepam on Arousability and Cheyne-Stokes Respiration. Sleep 1993, 16: 529-538. PMID: 8235237, DOI: 10.1093/sleep/16.6.529.Peer-Reviewed Original ResearchConceptsCheyne-Stokes respirationCongestive heart failureTotal sleep timePercentage of TSTApnea/hypopnea indexOxygen saturationTotal wake timeEffects of temazepamHeart failureSleep architectureDouble-blind crossover trialSevere congestive heart failureOvernight oxygen saturationStage 1 sleepHours of sleepSleep stage proportionsCHF patientsHypopnea indexMale patientsDaytime somnolenceCrossover trialSignificant changesFrequent arousalsDaytime alertnessSleep timeEffects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease
Steens R, Pouliot Z, Millar T, Kryger M, George C. Effects of Zolpidem and Triazolam on Sleep and Respiration in Mild to Moderate Chronic Obstructive Pulmonary Disease. Sleep 1993, 16: 318-326. PMID: 8341892, DOI: 10.1093/sleep/16.4.318.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseModerate chronic obstructive pulmonary diseaseObstructive pulmonary diseaseEffects of zolpidemPulmonary diseaseDrug conditionsNocturnal arterial oxygen desaturationArterial oxygen desaturationApnea-hypopnea indexGroup of patientsArterial oxygen saturationNumber of awakeningsTotal sleep timeHours of sleepSignificant differencesSubjective sleep variablesNew hypnotic agentOxygen desaturationCrossover studyHypnotic agentsSleep problemsSleep qualityOxygen saturationSleep efficiencyActive drug
1992
MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA
Kryger M. MANAGEMENT OF OBSTRUCTIVE SLEEP APNEA. Clinics In Chest Medicine 1992, 13: 481-492. PMID: 1521414, DOI: 10.1016/s0272-5231(21)00875-3.Peer-Reviewed Original ResearchConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaNasal continuous positive airway pressureBilevel positive airway pressureContinuous positive airway pressureGeneral therapeutic measuresUpper airway abnormalitiesMinority of patientsLong-term efficacyHours of sleepHypopnea frequencyAirway abnormalitiesObese patientsSurgical managementDrug therapyTherapeutic measuresEffective treatmentPatientsSpecific abnormalitiesApneaWeight lossTreatmentAbnormalities