1988
Sleep Apnea and Body Position during Sleep
George C, Millar T, Kryger M. Sleep Apnea and Body Position during Sleep. Sleep 1988, 11: 90-99. PMID: 3363274, DOI: 10.1093/sleep/11.1.90.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexRapid eye movementLateral decubitus positionApnea durationObese patientsSleep apneaDecubitus positionBody positionSleep stagesSevere sleep apneaObstructive sleep apneaNon-REM sleepMajor treatment interventionApnea frequencyOvernight studyPatientsTreatment interventionsApneaNREMEye movementsSleepPrevious studiesPolysomnogramSupinePosition changes
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence