2024
Corrigendum to “PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein” [Molecul. Cellul. Endocrinol. 595 (2025) 112412]
Yao G, Zhu M, Insogna K. Corrigendum to “PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein” [Molecul. Cellul. Endocrinol. 595 (2025) 112412]. Molecular And Cellular Endocrinology 2024, 112429. PMID: 39616004, DOI: 10.1016/j.mce.2024.112429.Peer-Reviewed Original ResearchPTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein
Yao G, Zhu M, Insogna K. PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein. Molecular And Cellular Endocrinology 2024, 595: 112412. PMID: 39536935, DOI: 10.1016/j.mce.2024.112412.Peer-Reviewed Original ResearchReceptor activator of nuclear factor kappa-B ligandReceptor activator of nuclear factor kappa-B ligand mRNAAU-rich elementsParathyroid hormone treatmentParathyroid hormoneMRNA stabilityRegulation of mRNA stabilityAU-rich element-binding proteinBinding to AU-rich elementsActivation of transcriptionInhibition of cellular transcriptionRegulate mRNA stabilityCells treated with vehicleSplicing regulatory proteinKH-type splicing regulatory proteinNuclear factor kappa-B ligandAu-richElement-binding proteinTNF family membersCellular transcriptionAssociated with increased phosphorylationPTH exposureRegulatory proteinsBinding proteinCells pre-treatedMitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis
Zhu M, Zeiss C, Hamrick M, Weinstein R, Sun B, Brotto M, Liu X, Siu E, Huttner A, Tommasini S, Simpson C, Insogna K. Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis. Bone 2024, 184: 117086. PMID: 38552893, DOI: 10.1016/j.bone.2024.117086.Peer-Reviewed Original ResearchConceptsDeletion of Mfn2Bone mineral densityMitofusin 2Reduced expression of Mfn2Myofiber atrophySpinal cordTransgenic mice expressing CreMice expressing CreNon-redundant roleSkeletal muscle histologyLumbar spinal cordTrabecular bone massLean body massExpression of Mfn2Mitochondrial reticulumMFN2 geneDisruption of cellular architectureImpaired osteoblast differentiationOsteoblast lineage commitmentMfn2Mitochondrial sizeMitofusinMineral densityCo-expressionDisorganized sarcomeres
2015
Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age‐Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo
Zhu M, Sun B, Saar K, Simpson C, Troiano N, Dallas SL, Tiede‐Lewis L, Nevius E, Pereira JP, Weinstein RS, Tommasini SM, Insogna KL. Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age‐Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo. Journal Of Bone And Mineral Research 2015, 31: 864-873. PMID: 26496249, PMCID: PMC4826801, DOI: 10.1002/jbmr.2733.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryBone mineral densityDKO miceParathyroid hormoneOsteoclast numberDKO animalsSerum cross-linked C-telopeptideCross-linked C-telopeptideDaily parathyroid hormoneTrabecular bone massX-ray absorptiometryMetaphyseal trabecular boneNormal differentiation markersAge-dependent changesC-telopeptideMineral densityBone massBone densityActin ring formationSkeletal metabolismOsteoblast numberTooth eruptionResorptive activityNormal responseFocal disruption