2024
PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein
Yao G, Zhu M, Insogna K. PTH-dependent stabilization of RANKL mRNA is associated with increased phosphorylation of the KH-type splicing regulatory protein. Molecular And Cellular Endocrinology 2024, 595: 112412. PMID: 39536935, DOI: 10.1016/j.mce.2024.112412.Peer-Reviewed Original ResearchReceptor activator of nuclear factor kappa-B ligandReceptor activator of nuclear factor kappa-B ligand mRNAAU-rich elementsParathyroid hormone treatmentParathyroid hormoneMRNA stabilityRegulation of mRNA stabilityAU-rich element-binding proteinBinding to AU-rich elementsActivation of transcriptionInhibition of cellular transcriptionRegulate mRNA stabilityCells treated with vehicleSplicing regulatory proteinKH-type splicing regulatory proteinNuclear factor kappa-B ligandAu-richElement-binding proteinTNF family membersCellular transcriptionAssociated with increased phosphorylationPTH exposureRegulatory proteinsBinding proteinCells pre-treated
2015
Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age‐Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo
Zhu M, Sun B, Saar K, Simpson C, Troiano N, Dallas SL, Tiede‐Lewis L, Nevius E, Pereira JP, Weinstein RS, Tommasini SM, Insogna KL. Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age‐Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo. Journal Of Bone And Mineral Research 2015, 31: 864-873. PMID: 26496249, PMCID: PMC4826801, DOI: 10.1002/jbmr.2733.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryBone mineral densityDKO miceParathyroid hormoneOsteoclast numberDKO animalsSerum cross-linked C-telopeptideCross-linked C-telopeptideDaily parathyroid hormoneTrabecular bone massX-ray absorptiometryMetaphyseal trabecular boneNormal differentiation markersAge-dependent changesC-telopeptideMineral densityBone massBone densityActin ring formationSkeletal metabolismOsteoblast numberTooth eruptionResorptive activityNormal responseFocal disruption