Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication
Hsu JC, Laurent-Rolle M, Pawlak JB, Xia H, Kunte A, Hee JS, Lim J, Harris LD, Wood JM, Evans GB, Shi PY, Grove TL, Almo SC, Cresswell P. Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication. Molecular Cell 2022, 82: 1631-1642.e6. PMID: 35316659, PMCID: PMC9081181, DOI: 10.1016/j.molcel.2022.02.031.Peer-Reviewed Original ResearchConceptsInterferon-stimulated genesS-adenosyl methionineTranslation inhibitionRadical S-adenosyl methionineInnate immune responseIntegrated stress response pathwayStress response pathwaysViral RNA translationImmune responseAntiviral responseInnate immunityAntiviral mechanismTranslation regulatorsTranslational repressionViral replicationEnzymatic productDidehydro-CTPResponse pathwaysRNA translationViperinSAM activityPathwayInhibitionBroad spectrumReplication