2009
Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference
Brunzell DH, Mineur YS, Neve RL, Picciotto MR. Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference. Neuropsychopharmacology 2009, 34: 1993-2001. PMID: 19212318, PMCID: PMC2709692, DOI: 10.1038/npp.2009.11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, PsychologicalCuesCyclic AMP Response Element-Binding ProteinDecision MakingDose-Response Relationship, DrugDown-RegulationGene Transfer TechniquesMaleMiceMice, Inbred C57BLNicotineNicotinic AgonistsNucleus AccumbensPhosphorylationRewardSynaptic TransmissionTobacco Use DisorderUp-RegulationConceptsCyclic AMP response element binding proteinNAc shellPlace preferenceNicotine CPPCREB activityModulation of cocaineCREB activationNicotine place preferenceAbility of nicotineAbsence of nicotineCue-induced responsesDominant-negative CREB constructNicotinic acetylcholine receptorsAMP response element binding proteinLevels of CREBTranscription factor cyclic AMP response element binding proteinViral-mediated gene transferRange of dosesActivation of intracellularNicotine exposureMorphine rewardC57BL/6J miceNicotine rewardDopamine neuronsLong-term consequences
2006
Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice
Steiner RC, Hsiung HM, Picciotto MR. Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice. Behavioural Brain Research 2006, 171: 56-62. PMID: 16621045, DOI: 10.1016/j.bbr.2006.03.022.Peer-Reviewed Original ResearchConceptsKnockout miceLocomotor sensitizationCocaine-induced locomotor sensitizationAmphetamine-regulated transcriptEffects of psychostimulantsRange of dosesAcute cocaineBone resorptionAmphetamine injectionsNucleus accumbensIntravenous cocaineIntact animalsMiceCocaineSchedule of reinforcementInsulin regulationCART geneSensitizationWild-type siblingsPhysiological functionsRegulatory roleStriatumAccumbensPsychostimulantsRats