2022
Nicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2022, 4083-4101. DOI: 10.1007/978-3-030-88832-9_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties
2016
Nicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2016, 3659-3677. DOI: 10.1007/978-1-4939-3474-4_157.ChaptersTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties
2015
Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress
Mineur YS, Fote GM, Blakeman S, Cahuzac EL, Newbold SA, Picciotto MR. Multiple Nicotinic Acetylcholine Receptor Subtypes in the Mouse Amygdala Regulate Affective Behaviors and Response to Social Stress. Neuropsychopharmacology 2015, 41: 1579-1587. PMID: 26471256, PMCID: PMC4832019, DOI: 10.1038/npp.2015.316.Peer-Reviewed Original ResearchConceptsDepression-like behaviorBasolateral amygdalaΑ7 nAChRsCholinergic signalingMultiple nicotinic acetylcholine receptor subtypesNon-selective nAChR antagonist mecamylamineNicotinic acetylcholine receptor activityNicotinic acetylcholine receptor subtypesStress-mediated behaviorsAntidepressant-like effectsAcetylcholine receptor activityC-Fos immunoreactivityNAChR antagonist mecamylamineAcetylcholine receptor subtypesEffects of nicotineMajor depressive disorderSocial defeat stressAnxiety-like behaviorPre-clinical studiesHuman clinical trialsModels of anxietyMouse behavioral modelsHypercholinergic stateAntagonist mecamylamineLocal infusionNicotine Pharmacology, Abuse, and Addiction
Miller M, Picciotto M. Nicotine Pharmacology, Abuse, and Addiction. 2015, 1-19. DOI: 10.1007/978-1-4614-6434-1_157-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsTobacco useDrugs of abuseNeuropsychiatric disordersGreat public health relevanceGreat public health concernMesolimbic dopamine systemPre-clinical studiesPublic health concernPublic health relevanceNicotinic acetylcholine receptorsIonotropic neurotransmitter receptorsPrimary psychoactive componentSubstantial health risksNicotine exposureNicotine actsSustained tobacco useNicotine pharmacologyRewarding effectsNicotine addictionDopamine systemNervous systemNeurotransmitter receptorsNicotine useAcetylcholine receptorsAddictive properties
2009
Biological Basis for the Co-morbidity Between Smoking and Mood Disorders
Mineur YS, Picciotto MR. Biological Basis for the Co-morbidity Between Smoking and Mood Disorders. Journal Of Dual Diagnosis 2009, 5: 122-130. PMID: 20046987, PMCID: PMC2707026, DOI: 10.1080/15504260902869964.Peer-Reviewed Original ResearchNicotinic antagonistsCholinergic activityDepressed patientsMood disordersNicotinic receptorsNicotine dependenceHigh-affinity nicotinic receptorsChronic nicotine useMajor preventable causeEpisodes of depressionPre-clinical studiesClassical antidepressantsAdjunct therapyPreventable causeDepressive disorderMajor depressionUnderlying biological factorsDepressive symptomsNicotine useSmokingDepressionAntidepressantsDisordersHuman subjectsPatients