2020
FPGA Accelerated Analysis of Boolean Gene Regulatory Networks
Manica M, Polig R, Purandare M, Mathis R, Hagleitner C, Martínez M. FPGA Accelerated Analysis of Boolean Gene Regulatory Networks. IEEE/ACM Transactions On Computational Biology And Bioinformatics 2020, 17: 2141-2147. PMID: 31494553, DOI: 10.1109/tcbb.2019.2936836.Peer-Reviewed Original ResearchConceptsQualitative models of gene regulatory networksModels of gene regulatory networksAdvanced high-throughput technologiesGene regulatory networksHigh-throughput technologiesComplex molecular networkBoolean modelRegulatory networksBiological insightsT-cell large granular lymphocytic leukemiaMolecular networksAttractor detectionField Programmable Gate ArrayLarge granular lymphocytic leukemiaSoftware simulation toolGranular lymphocytic leukemiaSimulation toolPerformance improvementReconfigurable integrated circuits
2010
Messenger RNA fluctuations and regulatory RNAs shape the dynamics of a negative feedback loop
Martínez M, Soriano J, Tlusty T, Pilpel Y, Furman I. Messenger RNA fluctuations and regulatory RNAs shape the dynamics of a negative feedback loop. Physical Review E 2010, 81: 031924. PMID: 20365787, DOI: 10.1103/physreve.81.031924.Peer-Reviewed Original ResearchConceptsSingle-cell levelRegulatory RNAsGene expression variabilityIndividual cellsPost-transcriptional regulationNoncoding regulatory RNAsCell population levelNegative feedback loopSingle-cell experimentsRegulatory networksRNA transcriptsRepress translationRegulatory transcriptsPost-transcriptionallyExpression variabilityRNAStochastic eventsMessenger RNATranscriptionProtein expressionMessengerCell populationsPopulation levelCellsFeedback loop