Inferring clonal composition from multiple tumor biopsies
Manica M, Kim H, Mathis R, Chouvarine P, Rutishauser D, De Vargas Roditi L, Szalai B, Wagner U, Oehl K, Saba K, Pati A, Saez-Rodriguez J, Roy A, Parsons D, Wild P, Martínez M, Sumazin P. Inferring clonal composition from multiple tumor biopsies. Npj Systems Biology And Applications 2020, 6: 27. PMID: 32843649, PMCID: PMC7447821, DOI: 10.1038/s41540-020-00147-5.Peer-Reviewed Original ResearchConceptsCopy number alterationsEffects of copy number alterationsGenetic instabilityClonal evolutionClonal compositionDrug-resistant prostate cancerAcquisition of mutationsDrug-resistant subclonesPhylogeny reconstructionTumor phylogeniesRelative abundanceTumor biopsiesWilms tumorProstate cancerGenetic alterationsGenetic profileMultiple biopsiesTumor profilingHepatocellular carcinomaPhylogenyTumorSubclonesAnalysis of simulated dataMutationsBiopsy