High-throughput validation of ceRNA regulatory networks
Chiu H, Martínez M, Bansal M, Subramanian A, Golub T, Yang X, Sumazin P, Califano A. High-throughput validation of ceRNA regulatory networks. BMC Genomics 2017, 18: 418. PMID: 28558729, PMCID: PMC5450082, DOI: 10.1186/s12864-017-3790-7.Peer-Reviewed Original ResearchConceptsCeRNA interactionsMiRNA targetsCancer genesCompetitive endogenous RNAHigh-throughput validationIndirect regulatory influencesCellular contextMiRNA activityTumor contextMCF7 cellsTarget abundanceGenesPhysiological relevanceExperimental assaysCompetitive endogenous RNA networkAbundanceConclusionsOur resultsPredicted targetsTCGA profileMiRNAsRegulatory influenceEndogenous RNAResultsToRNABackgroundMicroRNAs