PCfun: a hybrid computational framework for systematic characterization of protein complex function
Sharma V, Fossati A, Ciuffa R, Buljan M, Williams E, Chen Z, Shao W, Pedrioli P, Purcell A, Martínez M, Song J, Manica M, Aebersold R, Li C. PCfun: a hybrid computational framework for systematic characterization of protein complex function. Briefings In Bioinformatics 2022, 23: bbac239. PMID: 35724564, PMCID: PMC9310514, DOI: 10.1093/bib/bbac239.Peer-Reviewed Original ResearchConceptsProtein complex functionGO termsProtein complex databasesGene Ontology (GONatural language processing techniquesRandom forestLanguage processing techniquesNearest neighborsProtein complexesSystematic annotationCellular statesBiological functionsBiological processesQuery vectorComplex queriesWord vectorsUnsupervised approachSupervised approachChild termsProteinMolecular biologySubunit compositionComplex databasesComplex functionsComputational framework