2024
Lessons learned from the IMMREP23 TCR-epitope prediction challenge
Nielsen M, Eugster A, Jensen M, Goel M, Tiffeau-Mayer A, Pelissier A, Valkiers S, Martínez M, Meynard-Piganeeau B, Greiff V, Mora T, Walczak A, Croce G, Moreno D, Gfeller D, Meysman P, Barton J. Lessons learned from the IMMREP23 TCR-epitope prediction challenge. ImmunoInformatics 2024, 16: 100045. DOI: 10.1016/j.immuno.2024.100045.Peer-Reviewed Original ResearchData leakageIssue of data leakageT cell receptorPerformance of proposed methodsPrediction challengeTraining dataBenchmarking CompetitionPMHC targetsRandom performanceTCR-pMHC interactionsInteraction of T-cell receptorsParticipating teamsCellular immune systemData setsTest dataImmune systemPerformanceNarrow spaceStochastic modeling of a gene regulatory network driving B cell development in germinal centers
Koshkin A, Herbach U, Martínez M, Gandrillon O, Crauste F. Stochastic modeling of a gene regulatory network driving B cell development in germinal centers. PLOS ONE 2024, 19: e0301022. PMID: 38547073, PMCID: PMC10977792, DOI: 10.1371/journal.pone.0301022.Peer-Reviewed Original ResearchConceptsGene regulatory network structureGene regulatory networksGene expression dataExpression dataB cell differentiationSingle-cellAssociated with cell developmentGC B cell differentiationStages of B-cell differentiationB cell developmentSelection of B cellsGene regulationRegulatory networksTranscriptome dataSystems biologyHigh-affinity antibodiesRegulatory mechanismsCell developmentGenesAdaptive immune systemMRNA distributionPlasmablast stageGerminal centersDifferentiationImmune system
2023
Computational modelling of immunological mechanisms: From statistical approaches to interpretable machine learning
Martínez M, Barberis M, Niarakis A. Computational modelling of immunological mechanisms: From statistical approaches to interpretable machine learning. ImmunoInformatics 2023, 12: 100029. DOI: 10.1016/j.immuno.2023.100029.Peer-Reviewed Original ResearchHigh-throughput experimental technologiesComputational biologyDevelopment of high-throughput experimental technologiesImmune systemHigh-throughput data analysisImmunological mechanismsMolecular functionsSystems biologyImmune-related diseasesOptimal immunotherapyTherapeutic optionsAutoimmune diseasesComplex disorderInterpretable machine learningMachine learning modelsCellular interactionsGeneration of computational modelsBiologyComputer scienceMachine learningMachine-learning modelsDiverse domainsLearning modelsExperimental technologyInterpretable machine