2024
Stochastic modeling of a gene regulatory network driving B cell development in germinal centers
Koshkin A, Herbach U, Martínez M, Gandrillon O, Crauste F. Stochastic modeling of a gene regulatory network driving B cell development in germinal centers. PLOS ONE 2024, 19: e0301022. PMID: 38547073, PMCID: PMC10977792, DOI: 10.1371/journal.pone.0301022.Peer-Reviewed Original ResearchConceptsGene regulatory network structureGene regulatory networksGene expression dataExpression dataB cell differentiationSingle-cellAssociated with cell developmentGC B cell differentiationStages of B-cell differentiationB cell developmentSelection of B cellsGene regulationRegulatory networksTranscriptome dataSystems biologyHigh-affinity antibodiesRegulatory mechanismsCell developmentGenesAdaptive immune systemMRNA distributionPlasmablast stageGerminal centersDifferentiationImmune system
2019
A Probabilistic Model of the Germinal Center Reaction
Thomas M, Klein U, Lygeros J, Martínez M. A Probabilistic Model of the Germinal Center Reaction. Frontiers In Immunology 2019, 10: 689. PMID: 31001283, PMCID: PMC6456718, DOI: 10.3389/fimmu.2019.00689.Peer-Reviewed Original ResearchConceptsB cell differentiationMemory B cell differentiationSpecialized compartmentsAntibody genesPlasma cell differentiationFate selectionB cellsIndividual cell propertiesCell differentiationB cell maturationMolecular eventsEfficient stochastic simulationExtracellular dynamicsQuantitative stochastic modelMemory B cell formationAntigen affinityB cell formationGillespie algorithmDifferentiationCell propertiesCell productionMemory B cells