Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial
Čuklina J, Lee C, Williams E, Sajic T, Collins B, Rodríguez Martínez M, Sharma V, Wendt F, Goetze S, Keele G, Wollscheid B, Aebersold R, Pedrioli P. Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial. Molecular Systems Biology 2021, 17: msb202110240. PMID: 34432947, PMCID: PMC8447595, DOI: 10.15252/msb.202110240.Peer-Reviewed Original ResearchConceptsBatch effectsProteomic studiesLarge-scale proteomic studiesCorrection of batch effectsMass spectrometry-based proteomicsStep-by-step protocolProteomic datasetsProteomic dataSystems biologyBatch correctionMultiple experimental designsProteomic ChallengeR packageProteomicsClinical proteomicsBiological signalsTechnical variabilityStatistical powerIntensity driftBiology